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Novel therapy (chlorogenic acid) for UC that has been highly effective for me.

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Ulcerative Colitis
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Posted 11/12/2012 12:16 AM (GMT 0)
I, too, would be interested in hearing from those who try it.

Richard in NY.....Thanks for posting.

Old Mike...why do you think it might work like LDN?
Posted 11/12/2012 1:24 AM (GMT 0)
It is an opioid receptor antagonists,please read my old threads from April that I linked.
But that may not be its mechanism if it works, it binds with LPS and down regulates TNF and NFKB, also
is antibacterial.
It is a polyphenol so may also do other things,perhaps some antioxidant capacity as well.
I just checked my bottle,that I bought in April, I only took one pill,I diluted one pill into 100 ml of water, and took partial teaspoons.
Old Mike

Post Edited (Old Mike) : 11/12/2012 5:34:33 AM (GMT-7)

Posted 11/12/2012 8:11 PM (GMT 0)

ItsAlwaysSomething said...
I, too, would be interested in hearing from those who try it.

So far so good for day 2.

Off pred, off licorice, reduced sulfasalazine.
Posted 11/12/2012 8:13 PM (GMT 0)

aguywithuc said...

ItsAlwaysSomething said...
I, too, would be interested in hearing from those who try it.

So far so good for day 2.

Off pred, off licorice, reduced sulfasalazine.

That's great. How many capsules a day are you taking, and what have your symptoms been like recently? If you're in remission, it's not going to be much of a test.
Posted 11/12/2012 9:25 PM (GMT 0)
I had 2 years of remission. Then I had the usual summer end flare when I took ABX. That forced an 8-week course of prednisone. I have been off prednisone for about a week and this is normally a very difficult transition which it started out to be - however I feel good now, workouts feel good now that pred is out of my system.

My symptoms would be I do not have perfect-poop and am going more than once per day. Less inflammation should improve things noticeably.

"Furthermore, it has been proven to be an immune system suppressor."

That would seem to be an alternative to prednisone if it is effective enough.

Post Edited (aguywithuc) : 11/12/2012 7:38:01 PM (GMT-7)

Posted 11/15/2012 3:24 PM (GMT 0)
Old Mike- I just noticed that sunflower seeds are second on the list for containing chlorogenic acid. Could this perhaps explain the spinach sunflower seed butter diet or yet add another possibility to the list of compounds that may be why?

Steve
Posted 11/15/2012 5:46 PM (GMT 0)
Twiggs: There is so many things going on not sure,chlorogenic acid,oxalic acid,vitamin K,high nitrate,high arginine,plus others.  Just don't know at this time.

Old Mike

Posted 11/15/2012 6:10 PM (GMT 0)
Old Mike I posted a new thread on Vitamin K. Take a look here is some very interesting relevant info I found and would love to hear your take on it.

Steve
Posted 11/15/2012 7:32 PM (GMT 0)
Just ordered some. Hope it comes soon. How much are you guys taking? I don't want to lose a lot of weight. Maybe 5#, but I do want my UC to stop reaking havoc on my mind and body. I will let you know how it goes.
AguywithUC-keep us posted on your progress.
Posted 11/15/2012 7:49 PM (GMT 0)

lemonhead said...
Just ordered some. Hope it comes soon. How much are you guys taking? I don't want to lose a lot of weight. Maybe 5#, but I do want my UC to stop reaking havoc on my mind and body. I will let you know how it goes.
AguywithUC-keep us posted on your progress.

I am taking 1 400mg capsule when I wake up and then another before or with each meal, so 4 per day. You didn't mention which brand you ordered but 400mg standardized to 50% chlorogenic acid seems to be the norm. They contain a little caffeine (12mg per capsule for the LEF product) so I don't take one too close to bedtime.

I seem to have plateaued with the benefit from the chlorogenic acid, at about a 60% reduction in symptoms from my flare. I discontinued rifaximin when I started the chlorogenic acid to see how much good it would do me. I started back on the rifaximin yesterday and I'm now very close to full remission. Just 3 BM's this morning, no urgency, firm stools, no gas, no cramping, etc.

It seems like the combination of the cholorogenic acid and rifaximin is my magic bullet (at least for now).

I am doing the happy dance, just so you know. :-)
Posted 11/16/2012 2:27 PM (GMT 0)
I got 400mg with 45% standardized chologenic acid. Puritans pride. I guess we will see, I am headed downhill fast, so I hope this helps.
Posted 11/16/2012 4:49 PM (GMT 0)
I got some "green coffee bean extract", 400mg, which is apparently 180-200 mg chlorogenic acid. So far no major change, now taking 2 in am, 2 in pm.
Posted 11/16/2012 5:58 PM (GMT 0)

freddyj said...
I got some "green coffee bean extract", 400mg, which is apparently 180-200 mg chlorogenic acid. So far no major change, now taking 2 in am, 2 in pm.

Yeah I noticed the same thing. So I am back on heavy ALA but not stopping the CA because I like how it can help me get my 6-pack back after the prednisone smoothout.
Posted 11/16/2012 6:22 PM (GMT 0)
I let my ala expire... took a month, didnt seem to be earth shattering. still on methyl folate.
Posted 11/18/2012 4:39 PM (GMT 0)
Any updates on the CA? Helping or not? Still have not received mine in the mail.....and having a bad flare. Not sure if I can wait any longer. May have to call the doc tomorrow.
Posted 11/18/2012 4:54 PM (GMT 0)

lemonhead said...
Any updates on the CA? Helping or not? Still have not received mine in the mail.....and having a bad flare. Not sure if I can wait any longer. May have to call the doc tomorrow.

It's still helping me.

Call the doctor and get on whatever med's you need to deal with the flare. You can always try the CA when it comes and your flare is under better control.

Good luck, and I'm sorry to hear you're flaring.
Posted 11/18/2012 7:51 PM (GMT 0)
yeah, me too. And for the holidays!! I hate this disease.
Posted 11/21/2012 2:05 PM (GMT 0)
Just got my CA yesterday. I took 3 yesterday. No difference this morning. I know it is early. Will try 4 today. How is everyone else doing?
Posted 11/21/2012 3:34 PM (GMT 0)

lemonhead said...
Just got my CA yesterday. I took 3 yesterday. No difference this morning. I know it is early. Will try 4 today. How is everyone else doing?

Are you still having a bad flare? That might be masking whatever benefit it's giving you.
Posted 11/21/2012 5:40 PM (GMT 0)
I have only been on it since yeaterday afternoon. I am guessing it is going to take a little longer than that!! Flare is annoying, but managable. After Sunday, I started to feel a bit better. Still have a little bit of blood, but it is better.
Wondering how FreddyJ and aguywithUC are doing on this?
Posted 11/21/2012 5:51 PM (GMT 0)
You can also try upping the dosage. Try 2 capsules 3 times a day and see if that makes a difference. It will also take some time for the inflammation to go down.
Posted 11/22/2012 12:49 AM (GMT 0)
I stopped the ALA but went back on it because I was not getting relief from CA. I had some trouble and realized it was from the gluten-free chips. They are made from rice but have corn in them. Stopped those and am returning to normal. Started up CA again and will see how it goes.

For me it has always been more about avoiding toxic foods than finding the key supplement although Pysllium Seed Powder still rocks, VSL#3DS and sunflower seeds after that. Hoping CA can be added to the list as it looks great on paper and is good for managing the waistline.
Posted 12/16/2012 1:04 AM (GMT 0)
Hi-
I ordered Pure Green Coffee Bean Extract 800mg with 100mg Raspberry Ketone (std to 50% chlorogenic acids) from Amazon and started taking it 10 days ago.

I take one 800 mg capsule in the morning 30 minutes before eating (as directed) and have a cup of green tea. Have stayed away from coffee so far. The product contains 20 mg of caffeine so no coffee withdrawal. Also no jitters.

I like this stuff for a couple of reasons. I feel more energetic and do not experience a 3 pm "slump". Also have been more motivated to go to the gym than before and have lost a few pounds (not a bad thing during the holiday season).

Because I'm active for most of the day (do not sit around), I sleep better at night.
I stopped using LDN for a while because it was interfering with my sleep and causing disturbing dreams.

I'm thinking about starting LDN again.
Any thoughts, Old Mike?
I'll have to read some of your older posts.
Posted 12/16/2012 1:45 AM (GMT 0)
Are you taking them to lose weight specifically? or for energy?

What exactly and why would one want to take the raspberry ketones?

q
Posted 12/16/2012 4:05 AM (GMT 0)
I just read through all of this, thanks for sharing Richard, and how is everyone doing with this??
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