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Imuran and Feeling Sick to my Stomach

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Ulcerative Colitis
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Posted 12/10/2012 11:01 PM (GMT 0)
Hi All,

Well I started Imuran about 7 weeks ago and it has really been working great for me. I got out of a really bad flare and am tapering off Pred, which I have been on for over a year. I even started gaining weight again, almost 8 pounds since I started the Imuran.... which seems like a miracle because I've lost so much weight since I got sick and have never been able to gain any back.

Only problem is starting a week ago I have been getting really nauseous about 1-2 hours after taking my dose. I always take it with food. Last night was the worst, I took it with dinner and about 2 hours later I threw up.

Now I'm scared to take it and have skipped my dose.

I called my Doc and he said to stay off it for 2 days then take half my regular dose. I was taking 100 mg's so now I will be taking 50 and he thinks this will make the sick feeling go away.

Anybody else experience this??
Posted 12/10/2012 11:23 PM (GMT 0)
I've never taken Imuran but that is somewhat common.
Posted 12/11/2012 12:13 AM (GMT 0)
Many take Imuran before bed to combat that nauseous feeling. Have you used Zofran?
Posted 12/11/2012 1:22 AM (GMT 0)
I have not tried zofran..... what is it? Anti Nausea med?
Posted 12/11/2012 1:28 AM (GMT 0)
zofran works REALLY well.
Posted 12/11/2012 3:30 AM (GMT 0)
So this is the first time I've ever posted here, but I feel as if my experience with imuran is relevant. I'm 27 now and have been battling UC since high school. I tried every drug out there (those that go down, as well as those that go up), and nothing worked... Until I started taking Imuran about a 18 months ago (200/mg). It has been a miracle drug for me, and I've been flare free since...

For about the first 3 months I would throw up randomly about 4-5 times a week. Obviously this was very inconvenient, however not nearly as inconvenient as UC flares. So my advice would be to just stick out the whole nausea stuff, small price to pay in the long run
Posted 12/11/2012 4:25 AM (GMT 0)
Thanks for the feedback Feelingbetter.

Would you take it at night to avoid some of the nausea?

Also anyone have an opinion on taking with food or on an empty stomach?
Posted 12/11/2012 4:54 AM (GMT 0)
Hi Matt - I've been on 100 mg of Imuran for 3 months now. And though I haven't thrown up do to the meds I've felt all around off. Dizzy, nauseous, breathing is off. I take it at night before bed. Any time you feel sick it's no fun. But I'd rather have these Imuran side effect then a flare. Right??
Posted 12/11/2012 4:54 AM (GMT 0)
Hi Matt - I've been on 100 mg of Imuran for 3 months now. And though I haven't thrown up do to the meds I've felt all around off. Dizzy, nauseous, breathing is off. I take it at night before bed. Any time you feel sick it's no fun. But I'd rather have these Imuran side effect then a flare. Right??
Posted 12/11/2012 8:43 AM (GMT 0)
Hi Matt,

I've recently come off Aza or Imuran - I couldnt handle the side effects - nausea, head aches, hair falling out, bones hurting, stomach cramps, diarreah...

It was the worst 10 weeks on any medication I've ever had! I took 150mg by the end but then my specialist nurse took me off it as she didnt like all the side effects I was experiencing...and my blood imflammation was quite high as well as my ESR...

Anyway I guess I just want to say that dont be afraid to tell your specialist that you dont like the medication and that you want to know other routes you can go down...however your sickness could taper off eventually, maybe try taking the 100mg but 50mg after breakfast and 50mg after your tea, spreading it out a bit? It does seem tpo be working for you - trust your instincts and also gain advise from your doctor...

Hope all goes well and good luck :)

Posted 12/11/2012 1:15 PM (GMT 0)
i would try taking the imuran at night beofre bed then.  its worth sticking with it to see if the side effects pass. In the beginning with imuran, i would get some stomach pains, but i stopped taking some other supplements (multivitamin etc) and since then, I have felt really good.

Posted 12/14/2012 5:59 PM (GMT 0)
Thanks for all the advice.

I am going down to 50 mg from 100 mg. The first day I took it with no sick feeling. The second day I felt sick again, so I think I will just tough it out and take it before bed and see how it goes. It is definitely working on my Colitis, so I don't want to stop taking it!!!
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