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Serotonin Amino Acid Manipulation - Results Log - Old Mike

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Ulcerative Colitis
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Posted 1/28/2013 8:02 PM (GMT 0)
Day 1. Started supplements yesterday. I take no meds,stopped other supplements, I smoke by choice

with this disease.

Not taking cofactors.

Now Brand Tyrosine 500mg  3x twice a day

Now Brand 5HTP 100mg chewable 1.5x twice a day

Bowel Movments-15+ lost count,no D, did have one footer plus,used at least 500 sheets.

Consistency- Mixed,soft paste, not D,some good ones.

Urgency- Pretty urgent,good thing did not have to go anywhere,some gut pain not too bad.

Blood-Only slight in AM first poo,some could be mixed with mucus when wiping hard to tell.

The interesting thing is the lack of blood,many days I can squirt.

I may back down to 1000mg and 100 tonight,starting slower seems appropriate for me,

difficult to tolerate 15 plus poo's a day for too many days. Could even back down lower to start,

see how tomorrow and rest of day goes. No nausea.

So far realy happy about lack of blood,we will see if that keeps up.

Hopefully I can stand the increased frequency,before anus gives out,actually not real sore.

As you can see I am real interested in this approach,posting poop length and such,but I learned

after my sons colectomy,pull no punches with this disease.

My advice,start out slow.

I can't get too excited about the amount of BM's,methyl folate and methly b12 did something like

this also.

Now that I have been off the pot for an hour, I will have a VO Manhatten,to soothe my butt.

Old Mike

Side effects from site

http://www.neurosciencemyths.com/Amino-acid-side-effect-management-1.pdf

http://www.neurosciencemyths.com/Amino-acid-side-effect-management-2.pdf

 

Post Edited (Old Mike) : 1/28/2013 3:39:29 PM (GMT-7)

Posted 1/28/2013 8:18 PM (GMT 0)
OM, I'll have to remind myself not to read and follow your progress while drinking coffee - I laughed so hard it came out my nose... In fact I'm still laughing. Good lord... I needed that actually.

email me your address and I'll FedEx a bulk supply of TP right to your doorstep along with some reading material for your troubles and efforts...

Just wanted to say thanks for all you done...

Mark

"In summary, the findings of the present study showed extensive changes seen in enteric nerves and infiltration of NOS and peptides immunoreactive inflammatory cells in the serosa layer of CD ileum, suggesting that nerve-immune interactions may play a significant part in the process of inflammatory changes seen in Crohn's ileitis. However, the exact mechanism(s) and degree of importance of the interactions in initiating and perpetuating the inflammatorv process meritfurther investigation."

Results of an old study (1997) dealing with the topic...
Posted 1/28/2013 8:19 PM (GMT 0)
We are all watching closely and are cheering you on! Thanks for posting!
Posted 1/28/2013 8:27 PM (GMT 0)
Mark: Glad you enjoyed it, and had a good laugh,we buy Scott 1000 sheet rolls in the 24 pack.
When we go to visit my daughter,I bring my own TP supply,otherwise I would deplete
her stock of the 500 sheet rolls in no time.
I have to give this a plus for the first day,I have not bled to death, and see no mental changes.
Old Mike
Posted 1/28/2013 11:00 PM (GMT 0)
My bottle of 5HTP says not to take if you have UC so when flaring I skip it.

Are you saying there is evidence it is helpful ?
Posted 1/28/2013 11:07 PM (GMT 0)
Aguywithuc: You must have missed this whole thread.
Old Mike
https://www.healingwell.com/community/default.aspx?f=38&m=2621363
Posted 1/28/2013 11:47 PM (GMT 0)
I have to get caught up on this experiment. :)
Posted 1/29/2013 3:15 AM (GMT 0)
OM - perhaps you could send me an email when you have chance.

Thanks

All the best :)

Mark
Posted 1/29/2013 1:33 PM (GMT 0)
Day two so far.
Backed down to 500mg/50mg,last night.
This am some blood initial before poo came out.
Formed not much so far, actually after yesterday,can't imagine there is much in
the colon.
Today will go with 1000/100 2x,unless colon is hyperactive again.
Old Mike
Posted 1/30/2013 1:56 AM (GMT 0)
OM - I've been thinking about this for a few days now... If I made the all the arrangements would you do this along with me? Just that you're the only one NOT on any medication with a very long history AND a genetic offspring with the same condition it seems from what I have read. Makes you good, well... candidate I guess. No offence intended :) ! Anyway.... Though I really don't know to much about how bad you have UC or how severe it affects you.

I think it would be pretty invaluable to the cause here. Any success could in no way be attributed to meds. And well, failure would be very clear as well, as one could not say the meds interfered with the treatment protocol.

Please let me know. I think I could work things out to cover this.

Also - the groundhog thing made me laugh. Sounds like something my step dad in Michigan would do! To funny.
Posted 1/30/2013 2:04 AM (GMT 0)
Thanks for the offer Mark,but prefer to experiment/kill myself on my own.
I can tell you that the only thing that seems to help is low veggie oil diet,plus fish oil. Which I stopped for now.
Whey protein may also have helped.
I have not tried massive doses of tumeric which I may try at a later date.
I am going to back off of the 5htp for now,belive it could be a problem. I can't afford to make things worse.
Old Mike

Post Edited (Old Mike) : 1/29/2013 7:11:41 PM (GMT-7)

Posted 1/30/2013 2:31 AM (GMT 0)
Ok - I'll forward you the starting doses/instructions and such as soon as I get them. Hopefully it will help you figure things out.
Posted 1/30/2013 2:42 AM (GMT 0)

Old Mike said...
Thanks for the offer Mark,but prefer to experiment/kill myself on my own.
I can tell you that the only thing that seems to help is low veggie oil diet,plus fish oil. Which I stopped for now.
Whey protein may also have helped.
I have not tried massive doses of tumeric which I may try at a later date.
I am going to back off of the 5htp for now,belive it could be a problem. I can't afford to make things worse.
Old Mike

I should have tried that recently. I used to do that, 2 big tablespoons in 8 oz glass of warm water first thing in the morning resulted in perfect poop. I think too much can also cause diarrhhea and not sure why I never did it again. Scratch that I remember, turmeric permanently stains everything and after a mess happened I found other promising remedies more attractive. I used turmeric from the grocer - the ordinary spice.
Posted 1/30/2013 12:08 PM (GMT 0)
Experiment-TERMINATED
Crapping in the AM and half the day is one thing,crapping at midnight not for me.

Good luck to everyone else.

I need to re-look at rate limiting steps in serotonin pathway.
Old Mike
Posted 1/30/2013 1:45 PM (GMT 0)
Good work giving this a shot - your courage is inspirational. Sorry it was a flop for you and I hope you recover soon.
Posted 2/1/2013 12:01 AM (GMT 0)
OM - what should I do with these instructions? I want to share them - and at the same time I don't want to cause issue between the doc and I... respect his privacy, time and efforts etc. He did take some time to type this all up for me...

Was just thinking maybe they can be circulated to those interested in another manner rather than on the public forum perhaps.

Any thoughts/ideas.

Hard to keep both sides of the fence happy here!
Posted 2/1/2013 12:29 AM (GMT 0)
Does this site have the ability to private message each other?
Posted 2/1/2013 3:46 AM (GMT 0)
Mark: Really not sure how to do that. Check with moderators, But then again you did pay for it,but then again may have some sort of copyright.
Old Mike
Posted 2/1/2013 4:48 AM (GMT 0)
No private message thing on here that I can see.

How about we go back to what I suggested earlier - click on my name which takes you to my profile - and send me an email (which I have listed on there) - I'll respond to that.

My other hesitation is a liability thing if someone tried the first steps and ended up well... in a worse position Just not sure how to handle all that at the moment. More out of concern for others. I have multiple doctors supervision through this - others may not.

You should however read what is said.
Posted 2/1/2013 5:08 AM (GMT 0)
Same applies to you freddyj
Posted 2/1/2013 4:05 PM (GMT 0)
Not to side track but thought here would be a good place to ask OM this.

Have you tried Cats Claw?

Antiinflammatory actions of cat's claw: the role of NF-kappaB.

http://www.ncbi.nlm.nih.gov/pubmed/9882039


 

Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content.

http://www.ncbi.nlm.nih.gov/pubmed/12120814

Uncaria tomentosa acts as a potent TNF-alpha inhibitor through NF-kappaB.

http://www.ncbi.nlm.nih.gov/pubmed/19995599


Steve

Post Edited (twiggs) : 2/1/2013 9:14:21 AM (GMT-7)

Posted 2/1/2013 4:15 PM (GMT 0)
I am guessing tried cats claw over 20 years ago,but I will perhaps revisit
at high dose.
Old Mike
Posted 2/1/2013 4:20 PM (GMT 0)
I am going to get some cats claw at walgreens on my way home tonight from work. I will try this before I get the L-tyrosine to see how it works for me. Will let you know.

Good link on dosing etc...

http://www.intelihealth.com/IH/ihtIH/WSIHW000/8513/31402/347002.html?d=dmtContent

Steve

Posted 2/1/2013 4:29 PM (GMT 0)
Fearless Mike, is what we should call you!

I'd also like to recommend Inflaguard. Combination of boswellia, turmeric and devils claw. www.douglaslabs.com/pdf/pds/inf.pdf.
Posted 2/1/2013 4:36 PM (GMT 0)
Make sure what you buy is the uncaria tomentosa and not the uncaria guianensis, Most of the good digestive and immune system benefits come from that variety or portion. Can't remember the difference, might be part of the plant it's taken from...

It sucks though I've been taking it for years but it's becoming scacer in South America because of deforestization and sprawl.
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