Resoleomics

Possibly our problem in a nutshell. Our inflammation resolving switch is

not turned on.  Why it is just us and not everyone on a western diet,I would love to figure out. Perhaps we have

killed off lipoxin expressing bacteria in the gut,who knows.

There seems to be two choices with IBD,suppress inflammation or resolve inflammation.

I choose to resolve inflammation. Trying to get it to work is another story.

Old Mike

http://www.nutritionandmetabolism.com/content/9/1/32

http://www.westonaprice.org/know-your-fats/tripping-lightly-down-the-prostaglandin-pathways

might as well put zinc into the mix. page down.

http://www.cell.com/cell-reports/fulltext/S2211-1247(13)00016-8

fish oil enema mice

http://www.turkgastro.org/text.php?id=106

in person

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104159/

food consumption 1909-forward

http://www.cnpp.usda.gov/publications/foodsupply/foodsupply1909-2004report.pdf

good page

http://chriskresser.com/the-definitive-fish-oil-buyers-guide

Post Edited (Old Mike) : 3/4/2013 2:03:27 PM (GMT-7)

pb4 said...
Whatever shut our switch off needs to be dealt with I guess in order to possibly fix the problem.

bingo..

Many have tried boswella myself included,some say it works good,I think Probiotic said it has liver toxicity issues. But then again if you get the linoleic down,epa/dha,linolenic up it might work better.

I might revisit again using the 5-loxin.
Old Mike

Post Edited (Old Mike) : 3/1/2013 9:30:43 AM (GMT-7)

Yes,I am including flax seed oil also,been researching this for some time.
I have a lot more info in my resolvin E1 thread.
That being said,they had trialed large doses of fish oil for UC,with mixed results,in japan they
also have tried fish oil with perilla oil,with some intesting results on maintaining remission,but not induciton of remission.
There is still some secret,to induce remission wish I knew what it was.

Trying to check out what might be messing with our enzyme systems,but it is a long biochemical slog,

of which I am ill equipped to do. Just fixing the n6/n3 ratio,may go a long way,but not quite far enough.

Then again it may take a long time to get much of the LA out of your stored fat,and lipids.

Might as well through in excess sugar,alcohol and even to much linolenic messing with desaturase enzymes.

So complicated,so little time.
Old Mike

Post Edited (Old Mike) : 2/28/2013 3:40:40 PM (GMT-7)

FYI - OM

STOP SIGNAL According to the article:

NE is equal to the level of cortisol plus insulin and when cortisol sensitivity is recovered.

-------------------------
NE is Norepinephrine:
Norepinephrine is synthesized from dopamine

Cortisol induces tryptophan oxygenase (reducing serotonin levels in the brain)

Insulin is also used as a control signal for amino acid uptake by body cells

--------------------------------

Notice something familiar??????????????????????????????????????????

Haha

I seriously gotta get back to what I was doing but I'll put some time into this one fore sure later tonight perhaps... darn... now I'm totally distracted though.

Excellent find!

Actually I have a bunch of stuff for you at some point... Just finding time to root through all this stuff. I made a nice flowchart though. Helps organize thoughts....

I keep meaning to ask if med's ever put you in remission or if you just don't respond to them? Or is it a personal choice not to take them?

I hate them - but take them when I get exhausted from suffering.