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Zinc L-Carnosine

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Ulcerative Colitis
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Posted 4/19/2013 4:04 AM (GMT 0)
I have heard from a few people this is effective for UC. Does anybody have a bad experience with this supplement to report ?

Thanks
Posted 4/19/2013 8:53 AM (GMT 0)
Hi,

I have been using both these supplements and i have had a good reaction. However i do not take them directly, i get my zink from having a shot of powdered wheat grass every morning which is also good for cleansing the digestive tract and i get my L-carnosine from taking an amino acid/protein drink. I started on the amino acid drink due to a post i read on here about the disease linking to Amino acid inbalance and it seems to be working.

Also added sunflower seeds,butter,bread to the diet seems to be positive.

Hope this helps

Posted 4/20/2013 3:28 AM (GMT 0)

derby county said...
Hi,
I have been using both these supplements and i have had a good reaction. However i do not take them directly, i get my zink from having a shot of powdered wheat grass every morning which is also good for cleansing the digestive tract and i get my L-carnosine from taking an amino acid/protein drink. I started on the amino acid drink due to a post i read on here about the disease linking to Amino acid inbalance and it seems to be working.

Also added sunflower seeds,butter,bread to the diet seems to be positive.

Hope this helps

I'm off the UC meds and doing great with RS diet but some of those folks are saying zinc L-carnosine as a combined molecule is good for them.

Zinc L-Carnosine
Zinc L-carnosine is an amino acid chelate that has recently been recognized for its antiulcer effects. It appears to work by readily adhering to ulcer sites, [xxviii] reducing the inflammatory response. [xxxvi] Using animal models of inflammatory bowel disease, researchers have found that zinc L-carnosine prevented colon mucosal cells from inflammation and cellular damage. [xxxvii] [xxxviii]
Posted 4/20/2013 12:06 PM (GMT 0)
I have been thinking about trying it since it reduces advanced glycation endproducts both ones
and ones you already have. Just the l carnosine, not the zinc.

There is a patent on the zinc carnosine for UC,who knows.
Old Mike

Post Edited (Old Mike) : 4/20/2013 6:25:15 AM (GMT-6)

Posted 4/20/2013 12:12 PM (GMT 0)
I have used it for 2 months. The research that was sent to me by PepZinGI was very positive but I did not see any effect.
Posted 4/20/2013 10:36 PM (GMT 0)

deltaforce said...
I have used it for 2 months. The research that was sent to me by PepZinGI was very positive but I did not see any effect.

or any harm - ok thanks for the info.
Posted 4/20/2013 11:05 PM (GMT 0)
No harm as such, at least did not notice any. I took it when I was in flare and from the literature that those guys sent me sort of hinted that it could control the flare (because it did in mouse models) but it had absolutely zero effect.

There was no noticeable harm.
Posted 4/22/2013 2:22 AM (GMT 0)
I try to take most promising supplements at least once to see if it affects me. I have read that in laboratory animals of different species, carnosine supplementation extends life spans. But for some reason I have never tried carnosine until very recently.

I could not find Zinc L-carnosine but I have been taking zinc for years thru my multivite. Supposedly many Chronies are deficient because zinc is absorbed in the small intestines and that might explain why some with fistulas and abscess heal slowly. Zinc is vital for tissue repair.

So I tried carnosine alone and I am not sure but I think it helps. I figure my body is smart enough to put 2 and 2 together and let my available zinc work synergistically with the carnosine. The jury is still out and I want to continue it longer before including it in my signature. It seems promising.

ForMySon said...
Here is what my book, Inside Tract, by Gerad Mullin (excellent book and author who is the head of Integrative Gastroenterolgy at Johns Hopkins - also a masters degree in clinical nutrition) says about zinc carnosine:
"Zinc L-carnosine - a form of zinc that is bound to the amino acid L-carnosine - has a number of properties that guard the lining of your digestive tract. Clinically, zinc L-Carnosine has been found to protect the gut's mucosal lining." He cites a few studies demonstrating that in Crohn's patients, low zinc blood levels are common and that supplemention with zinc significantly decreased small intestinal permeability. He cites another study showing a correlation of correction of zinc deficiency and IBD improvement.


www.healingwell.com/community/default.aspx?f=38&m=2687863&p=4
Posted 4/22/2013 2:47 AM (GMT 0)
I started 1000mg L carnosine today,along with some zinc.
How much carnosine are you all taking,we have a carnase enzyme that destroys the carnosine so you need to take at least 500mg and better to take 1000mg.
Old Mike
Posted 4/22/2013 2:52 AM (GMT 0)
@Babe,
Will be glad if you could explain, how you think it is helping you, in terms of symptoms or anything else.
Posted 4/24/2013 12:07 PM (GMT 0)
I thought carnousine was helping, maybe it is a little, but nothing significant, if at all. Sometimes wanting something to work seems to help for a short while only.

But I did update my signature to reflect that Culturelle is my official stool solidifier. I have noticed this for well over a year but now there is no doubt that it works for me. So now when I feel a flare beginning I will add Culturelle to my other wonder drug which is creating a gunk of VSL#3DS mixed with powdered psyllium seed, along with apple sauce and blueberries.

I know Culturelle isn't compatible with everyone. I have seen several posts from people complaining that it gave them problems. But there is good research that the lactobacillus GG in Culturelle can be helpful for some and it definitely helps me. But I need at least several capsules a day to block a flare.

www.drhoffman.com/page.cfm/169
One of the most studied probiotics is lactobacillus GG. Children (median age, 14.5 years) with mildly to moderately active Crohn's disease despite therapy with prednisone and immunomodulatory drugs (such as 6-mercaptopurine, azathioprine, or methotrexate) were given Lactobacillus GG twice a day for six months. The median pediatric Crohn's disease activity index score at four weeks was 73% lower (better) than at baseline, and three patients had a score of less than 10, indicating inactive disease.

In some patients it was possible to taper the dose of prednisone by an average of 50% after 12 weeks of Lactobacillus GG treatment. Intestinal permeability, measured by a double sugar permeability test, improved in an almost parallel fashion. The researchers concluded that Lactobacillus GG may improve gut barrier function and clinical status in children with mildly to moderately active Crohn's disease.
Posted 4/25/2013 1:27 PM (GMT 0)
Babe,

without sounding dumb - Culturelle its a probiotic right? how many capsules do you take when in and out of flare?

Many thanks

Posted 4/25/2013 4:44 PM (GMT 0)
My maintenance regimen is 2 packets of VSL#3DS with powdered psyllium seed. But since VSL is so expensive, and that psyllium seed tastes terrible, I only take it every other day. On off days I take either 1 or 2 capsules of Culturelle or other probiotics that are cheaper. This is sufficient most of the time.

But if I eat something bad, inadvertently or otherwise, then I will sense a flare coming on. More frequent BMs with D or at least BMs that are less formed. That is when I take 3-4 capsules of Culturelle in the morning and another 3 at night on my off day, along with continuing my VSL3/psyllium seed regimen. Usually, (actually almost always), I am back to remission in a day or so. Of course this only works when I also stop eating the food that triggered problems in the first place.

The recommended dosage of Culturelle is one capsule a day. Taking more is expensive but I tell myself that it is cheaper than Asacol. Each capsule supposedly contains 10 billion CFUs. That is very little considering that each packet of VSL#3DS is almost 1 trillion CFUs. And you cannot believe everything you read on the label.

According to ConsumerLab.com:
"# Culturelle claimed to provide 10 billion cells in a daily capsule through the “best used by” date; ConsumerLab.com found only 5.8 billion viable cells. It is not clear whether this is a sufficient dose. Most clinical studies with Lactobacillus GG have used 10 to 20 billion viable cells per day. A dosing study (Saxelin 1991) using the bacteria in Culturelle (Lactobacillus GG) found that a daily dose of 1.5 billion cells was not able to colonize the gut, but a dose of 15 billion was. The amount found falls between these two dosages."
Posted 4/26/2013 8:11 AM (GMT 0)
babe, thanks for the advice much appreciated.

i have ordered a months supply ill see how i go.

cheers.

Posted 4/26/2013 11:55 AM (GMT 0)
Please be careful. Different probiotics affect each individual differently. Culturelle is compatible with me but I have seen posts from others that it causes problems.

I believe in using probiotics generously but only after you have found the strain that fits your body chemistry.
Posted 12/5/2014 3:38 AM (GMT 0)
Zinc cArnosine is good for Gastritis I had seen the effect of this on my GUT turn
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