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Problems switching from Asacol to Lialda

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Ulcerative Colitis
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Posted 7/5/2013 3:33 PM (GMT 0)
Ever since Kaiser switched me to Lialda, I've been having a serious flare (burning, cramping, urgency), and now am back on steriods. I think there is a problem with the way Lialda is released vs. Asacol, which was working for me. The coating seems to be different. Has anyone else experienced these problems? Lialda is a "time release" which Asacol is not. Asacol was working for me, but the new meds are a problem.
Posted 7/5/2013 3:36 PM (GMT 0)
I switched from Asacol to Lialda without issue. Have you considered Asacol HD? Perhaps that would work better for you... I started 6mp when I switched to Lialda so I can't say whether the Lialda does anything, maybe it's the 6mp helping.
Posted 7/5/2013 3:57 PM (GMT 0)
They are discontinuing Asacol period, HD or not. Kaiser has switched to Lialda as a replacement. I am not looking up the way Kaiser has instructed me to take it vs. what the studies indicate is useful. For instance, the study efficacy indicates you should take 4 doses early in the day, not later. You'd think my MD would have told me.....
Posted 7/5/2013 3:58 PM (GMT 0)

DavidF1Fan said...
Lialda is a "time release" which Asacol is not.

Actually, Lialda, Asacol, Asacol HD are all released based on the PH of your intestine (it is not a time-release as you suggest). Each of those medications uses a different coating, so there is most definitely a difference in the initial PH that it starts releasing medication, the rate in which medication is released, and so forth.

At the time of my initial diagnosis with uc, I was put on asacol HD, and I switched to Lialda about 4 months later for the convenience of taking my pills just once a day. My system was a little unhappy for about a week when I switched between them, but things settled down.
Posted 7/5/2013 4:19 PM (GMT 0)
this is from the resources thread:

➢ Sulfasalazine – diazo bond with sulfapyradine, colonic release
➢ Olsalazine (Dipentum®) - diazo bond of two 5-ASAs, colonic release
➢ Pentasa® - ethylcellulose/5-ASA beads, small bowel and colonic release
➢ Asacol® - Eudragit-S coating that releases at pH7, ileocolonic release
➢ Colazal® - diazo bond to inert polymer, colonic release
➢ Lialda® - Eudragit-S coating of metallomatrix 5-ASA, ileocolonic release
➢ Apriso® - Eudragit-L (pH6) coating of 5-ASA-polymer coated beads, small bowel and colonic release
➢ Asacol-HD® - Eudragit-S and Eudragit-L coating, ileocolonic release
➢ Canasa® suppositories – topical rectal release
➢ Rowasa® enemas – topical rectosigmoid releases
Posted 7/5/2013 4:43 PM (GMT 0)
THANK YOU!
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