PathogenKiller- My 23andMe Genetic Results

Well, here it is...the long-awaited results from 23andMe. I uploaded the data onto Geneticgenie.org and this is what i got:
METHYLATION RESULTS: the +/+ means homozygous mutation -but you prob already know that ;)

COMT V158M rs4680 AG +/-
COMT H62H rs4633 CT +/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MAO-A R297R rs6323 TT +/+
ACAT1-02 rs3741049 GG -/-
MTHFR C677T rs1801133 AA +/+
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 TT -/-
MTR A2756G rs1805087 AA -/-
MTRR A66G rs1801394 GG +/+
MTRR H595Y rs10380 CC -/-
MTRR K350A rs162036 AA -/-
MTRR R415T rs2287780 CC -/-
MTRR A664A rs1802059 GG -/-
BHMT-02 rs567754 CT +/-
BHMT-04 rs617219 AC +/-
BHMT-08 rs651852 TT +/+
AHCY-01 rs819147 CT +/-
AHCY-02 rs819134 AG +/-
AHCY-19 rs819171 CT +/-
CBS C699T rs234706 AG +/-
CBS A360A rs1801181 GG -/-
CBS N212N rs2298758 GG -/-
SHMT1 C1420T rs1979277 AG +/-

I did a blood test to measure my homocysteine level, folate and B12, it is a fasting one:
THcy: 13 H umol/L (5-12)
RBC Folate: 1391 nmol/L (>800)
S Total B12: 389 pmol/L (200-700)

Now i need to go grab a drink coz my head is spinning with this stuff, pitty it's not an alcoholic one but then 23andMe says i have a high risk for 'alcohol dependance'. Ha!
Also, anyone got a high risk for both Crohn's and UC? My risk is slightly higher for UC but i was like woof thank God that was a close call...

so what does this mean conq ? I don't read portuguese ?

I posted about this the other day. Saw the commercial and thought it looked interesting.

I have no idea what any of those results mean...

Been livin life lately cause I'm feeling really good ;) catching waves now that all the vacation crowd is gone.

So, yeah. It's a rabbit hole don't get too sucked in. However your homocysteine is high and you have some homozygous mutations to address. Homocysteine and mthfr have been linked in study after study with crappy outcomes.

Yasko would say to address shmt and CBS first.

My dr would say. That all you need to address is homocysteine and mthfr and the rest are corrolations made by shysters to get you to part with your money.

I am somewhere in the middle.
Didn't you say you reacted to sulfites/sulfates? Can't remember. Is so you may think about reading what Yasko and heart fixer have to say about CBS. Supporting shmt basically means supporting your gut. A digestive enzyme is something to look into. Also diet, eat anti inflammatory diet.

If I was you I'd start taking 5000 mcg sublingual methylcobalamin, and 1000mcg l-methylhydrofolate, titrating up 1000mcg each week to 5000 mcg a day. If you start having anxiety, back down. I'd take TMG to support the bhmt shortcut then switch to DMG to force the full methionine cycle. Try daily reg doses on the bottle. I like powder forms of those too so you can back down. It would be good to know your serum/plasma ammonia.. You may want to add molybdenum. You have one heterozygous CBS mutation, but high homocysteine which would indicate it's either not expressing or it's a down regulation of the enzyme. P5p will help in the latter case.

I'd also supplement Rda or more, but not too much, p5p.

Make sure you get atleast Rda magnesium.

You are likely to feel tired, cranky and fluish for ATLEASt a week. The tiredness may last longer... Do everything you can to concurrently detox. Sweating, Epsom salt baths, drink lots of water... Move your body and your lymph. If the toxic dump is too fast, scale back and titrate up slowly. I like shaking things loose fast so you can get back on track quicker. More unpleasant in the beginning.. Email me if I don't respond, but often I'm only on once every couple days now.

Whatever you do, don't get sucked into crazy whackamole with the snp junkies. Everyone and their brother is trying to pin chronic illness on a snp. The mthfr snps are the most studied, try and stay there. Your neurotransmitters should even out in a few months. You should be less, "tired but wired". You should get a more comprehensive report done at mthfrsupport. It will give you site into more potentially helpful info.

But first things first.. And to me, that means addressing mthfr 677 and mtrr 66a with lmethyl and b12. Then add the TMG and p5p. Good luck. It's good to know you have these mutations.

Ok great thanks sooo much for the reply i literally jumped in joy when i saw it lol, because i was seriously starting to get 'sucked' in as you said.

That's fantastic that you are enjoying summer! That's the way life should be. Im so happy for you. Go ahead and make the most of the sun and the warm weather :D

Ok i'll get started on these supplemnts right away, do you know a website that stocks these?

about COMTv158 and VDR Taq mutations: genetic genie said people withe these mutations "do not tolerate methyl donors well" and to rotate between hydroxyl b12, adenosyl b12 and methyl b12. What do you think about that?

Re anti inflamm diet: there are many definitions of that; do you mean low sugar, low carb, gluten free type diet?

EDIT: i just read on Amy Yasko's website that COMT +/- and VDR Taq +/- can tolerate "intermediate levels of methyl group donors". So the Methyl B12 is ok.

Post Edited (Conquer UC) : 8/23/2013 8:19:48 AM (GMT-6)

Haha Delta: true that! i've spent a couple of hours on Amy Yasko's website trying to get my head around it. It helps when you make your own summary of what the gene mutations affect.

It's all very interesting, like the VDR Taq gene is the vit D receptor gene and it affects my vitamin D levels which affect how much dopamine is produced, which in turn affects my susceptibility to catch infections. This gene science is fascinating!

Conquer, I don't worry about Comt and methyl donors because of vdr and mtrr.

But you could theoretically have a problem with b12 because nutrigenomics is a science of chasing unique snowflakes.

I believe in getting things spinning from the folate and methionine cycles then looking at bh4, nos/urea, krebs, and mitochondrial issues. However, if you have a boatload of homozygous blocks in one of those cycles you may consider addressing them sooner. Thats why paying 20 bucks for the mthfrsupport report is worthwhile. think Comt and Mao effect us allot because they drive neurotransmitters that control the gut. But it's hard to effect those directly. The hope is to get the cycles working right again with the two key supplements, b12 and lmethyltetrahydrofolate and that then everything else will work out its own kinks.

You can order lmethyl and b12 on amazon. Make sure they are free of wheat and lactose.

Post Edited (PathogenKiller) : 8/23/2013 9:01:43 AM (GMT-6)

UCandme: there is only one test on 23andme and yes it is the $99 test. That's what i ordered. Then once you recieve your results they tell you about the risk of certain diseases and your ability to metabolise most of the popular drugs including mercaptopurine (6mp). However they do not tell you about your methylation which is why you go on genetic genie.org and upload the results to get the methylation profile.
MTHFR mutations have been associated with many health conditions from IBS, IBD to CVD, multiple miscarriages, autism, anxiety, schizophrenia and more.
Therefore, for people like me who tend to react to every drug on the planet and do not respond in the expected way to medications, it makes sense to get tested and take the right supplements to override the mutation.

PK: i'm just about to do $20 test on mthfrsupport.com. There is just something which im not really understanding: if i'm homozygous for a particular gene say MTHFR C677T +/+, does that mean that the mutation MUST be expressing because BOTH copies are mutated?? If there is just one mutated copy, like with the CBS in my case, then it means that my enzyme is not working at full capacity because one copy is mutated, right?

I need a 'Genetics for Dummies' book....

P.S. I have the results of the MTHFRsupport.com report. Let me know what you want to know or if you want i can email it to you.

Post Edited (Conquer UC) : 8/23/2013 11:39:03 PM (GMT-6)

Thank you so much for the information and tip about life insurance.

Email it to me.

Also, anyone thinking about running 23andme I wouldn't rec using your real name on the 23andme report.

It will take me a few days to go over, fyi. Ill check soon..

Somedude LOL stop trolling around...
Honestly if i knew getting married and having kids would have brought all this on i would probably have stayed single :p
Yesterday i had a big fight with my MIL (mother in law) she is constantly interfering in my conversations with hubby and passing her own opinion when not asked...stupid wedding vows i'd have been more firm with her if she wasn't my MIL. She is going away for two months so it 'll just be my FIL for a while, thank God.