Prenatal methyl-donor supplementation augments colitis in young adult mice.

Its a shame they so severely overmethylated the mice with the amounts of nutrients they gave them

A human taking a max dose of 5000mcg/ 5mg *synthetic* folic acid a day is only taking(one really shouldnt take that much every single day, but lets just play with an upper range number)
.87mg/kg

whereas they dosed the mice
5mg/kg

5000mcg/5mg per day is 12.5 x the recommended daily dose

so the mice were being given 71x the rda of that one single nutrient. We know synthetic folic acid increases rates of cancer, both breast and corectal.. so it obviously contributes to cell changes

www.drfuhrman.com/library/folic_acid_dangers_and_prenatal_vitamins.aspx
www.greenmedinfo.com/blog/synthetic-folic-acid-may-contribute-colorectal-cancer2

In the group that were receiving not only that dose of folic, but also large, disproportionate doses of other MDs, it is no wonder they fared poorly. There is such a thing as being over methylated and that may be worse then being under methylated. The science is still out. We also have no idea of the mice's methyl deficit or tolerance.

There is talk about how multivitamin supplementation and nutritional fortification have raised the rates of autism because they are allowing children to be born that would have possibly not been if left to the parent's natural methylation capabilities.