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mesalamine intollerance

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Ulcerative Colitis
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Posted 9/26/2013 3:24 PM (GMT 0)
So I have been suspicious of this for quite some time. But, I have also been in a flare and stopping my lialda/rowasa/canasa wasn't an option.

However, this past weekend, I noticed that when I used a canasa, my pain/bleeding increased significantly. So then.. the next day I took off from using lialda and saw improvement... did the same on monday and saw more improvement.

Tuesday morning, I took lialda again and then wednesday morning had a noticeable increase in pain and bleeding.

I didn't take it yesterday, and today my pain/bleeding was much less.

For those of you that have mesalamine intollerance... does this sound like a possibility for me or is it just coincidental?  How do I find out or know for sure???

 

Posted 9/26/2013 3:34 PM (GMT 0)
Ask your dr. There are other uc medications available if you are.
Posted 9/26/2013 3:35 PM (GMT 0)
I should add I am allegic to sulfa drugs.
Posted 9/26/2013 5:17 PM (GMT 0)
I also had an adverse reaction to mesalamine - increased pain, bleeding, more stools, etc. I do tolerate Balsalazide as my 5-ASA. Other people have had this same experience, while some can't take any 5-ASA.
Posted 9/26/2013 5:33 PM (GMT 0)
How do I know for sure? Also, I wonder if the remicade that I started would in fact be sufficient on its own.  I also wonder if perhaps I didn't need the remicade and that all of this mess has just been because of the mesalamine. FRUSTRATING!!!!
Posted 9/27/2013 11:32 AM (GMT 0)
Calling GI today to find out what I should do. I definitely am improving since stopping all mesalamine (lialda/canasa/rowasa).

Still having a little bleeding, but pain is significantly down and this morning my bm was actually semi-formed! First time that has happened in months.
Posted 9/27/2013 12:17 PM (GMT 0)
That's how I found out that I'm intolerant of most mesalamines. I did fine on Colazal for about 6 years and than my body started to reject that as well. But oddly enough, I have no issue with Apriso (for now!). My Gi didn't feel that my Remi would be enough for me which is why I am on Apriso as well.
Posted 9/27/2013 2:34 PM (GMT 0)
OK GI said to stay off of all mesalamine for now. Supposed to check back in next week... meanwhile... hopefully the Remicade will take hold? Still taking some of the pred (down to 15mg), but was hoping to be off of that within the next week or so.
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