Another connection or hint:
Inspired by the aflatoxin and leafy green veggies effect:
I think you may have posted something on this earlier - but I've read so darn much I'm having trouble remembering everything in fine detail. I think it was seaweed... so that would tie into this perhaps. Leafy green and all.
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jn.nutrition.org/content/138/3/526.longNow although this article speaks of Aberrant crypt foci (ACF) and their role in colon cancer development. They are clusters of abnormal tube-like glands in the lining of the colon and rectum. Aberrant crypt foci form before colorectal polyps and are one of the earliest changes seen in the colon that may lead to cancer. From wiki. These produce both sialomucin and sulfomucin if I understood these correctly.
I'm curious if a) we posses any of these due to IBD and chronc inflammation - more so just curious. and b) well this would hint that straight from the ground (or immediately frozen), farm/backyard fresh watercress, green cabbage, and broccoli might be a good way to increase sulfomucin production for the protective effects.... I would assume leafy greens would fall into this category as well. Again it's not a strong connection but a hint perhaps...
Maybe something can be found on these veggies altering normal mucus producing cells expressing more sulfomucin as well?
It's a long paper so I'll cut an paste the paragraph that speaks of this:
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ACF = Aberrant crypt foci (aka funky abnormal mucus producing things)
The findings from Expt. 1 indicate that diets containing lyophilized watercress, green, or red cabbage were not protective against the formation of ACF. In studies using the aromatic amine 2-amino-3-methylimidazo{4,5-f}quinoline as the colon carcinogen, feeding rats cooked or raw red cabbage juice in drinking water before and during carcinogen treatment provided no protection against formation of ACF (8,25). Thus, cruciferous vegetables, when processed by either lyophilizing or juicing, seem to be ineffective in reducing colon cancer risk in animal models.
In contrast, our study found that watercress, green cabbage, and broccoli, incorporated into diets fresh and immediately frozen, were highly effective in reducing the number of total ACF and ACF producing sialomucin and sulfomucin in rats; fewer ACF tended to produce only sialomucin in rats fed the broccoli diet relative to the those fed the basal diet (Expt. 2). MDF number was also significantly lower in rats fed fresh cabbage and broccoli, with a trend for reduction in those fed watercress compared with the basal diet (P = 0.057). The difference between the 2 experiments is unlikely to be due to the additional week of feeding prior to carcinogen administration and longer feeding afterwards, because isothiocyanates and indole-3-carbinol have been shown to affect phase I enzymes within hours to days after exposure (26,27) and ACF number in the 2 basal groups did not differ (P = 0.19). As the vegetable-containing diets contained approximately the same total content of glucosinolates, and these cruciferous vegetables contain different predominant glucosinolates, our results suggest that the glucosinolates may not differ dramatically in their chemoprotective properties. Although rats fed the broccoli diet had significantly lower final body weights than rats fed the basal diet, final body weight did not explain the variations in ACF number among diet groups, suggesting that differences in ACF number were due to dietary differences, not differences in final body weight.
In Expt. 1, the quantity of vegetables consumed by the rats, on a fresh weight basis, ranged from 18.4 g/d for watercress to 30.7 g/d for red and green cabbage. In Expt. 2, the quantity of fresh vegetables consumed ranged from 3 g/d for watercress to 6.8 g/d for green cabbage. Thus, fresh vegetables were effective at reducing colon cancer risk at a dietary concentration of approximately one-fifth of that of the lyophilized vegetables, in fresh weight equivalents.
source:
jn.nutrition.org/content/138/3/526.long-------
All the more reason to eat fresh from the farm veggies..
Post Edited (Canada Mark) : 10/3/2013 1:38:43 AM (GMT-6)