Here OM,
I've mentioned this a few times but could never find where I saved the bookmark. Came across it just now when I was cleaning thing up.
Now it will be extremely interesting to find out what of this they find in Humans... and in IBD. Chances are good that missing these may be a good chunk of the puzzle. Or dysbiosis or PH change effects them and their metabolism by-products like "butyrate". There's another paper on this as well which I believe this one references which is the original study that found them.
I'm going to look in my books and read about
aerobic metabolism and byproducts. Actually now that I think about
it quickly a biofilm of anaerobic bacteria as in the 10,000 biopsy paper would be brutal to these aerobic bacteria. Specially with the pH change from the immune response to anaerobic bacteria I would think. Also I think back to the change in the glycosylax (forget how to spell that) - but the protective coating across epithelial cells where in UC it is missing in the infected areas and the same can also be seen in the 10,000 biopsy paper.
Also remember the anaerobic bacteria are deep in the crypts in the 10,000 biopsy paper where perhaps the aerobic bacteria should be instead.
A Crypt-Specific Core Microbiota Resides in the Mouse Colon:
www.ncbi.nlm.nih.gov/pmc/articles/PMC3372965/