Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis

Hey OM or anyone else... - have you been down this path at all?

Molecular link between gut microbes, intestinal health: Histone deacetylases 3 www.sciencedaily.com/releases/2013/11/131103140157.htm

I became curious tonight as to what makes a bacteria "commensal" or perhaps symbiotic. So what are the proposed ways in which we differentiate these bacteria from others. Especially since it now appears that they may live both above and below our mucus deep in our intestinal crypts.

It seems Histone deacetylases plays a role in Seratonin levels and Butyrate as well. ajpcell.physiology.org/content/304/4/C334

And it seems there's another player:
www.sciencedaily.com/releases/2013/08/130809084127.htm

What got me curious was this paper Phytoestrogen signaling and symbiotic gene activation are disrupted by endocrine-disrupting chemicals: www.ncbi.nlm.nih.gov/pmc/articles/PMC1241960/ from awhile ago on how plants use hormones through their estrogen receptors to signal to bacteria and EDC's in the environment disrupt this. So I was curious as to what is out there for proposed ways in which our bodies decide what can and cannot colonize our intestines and if this is somehow disrupted how it could apply to IBD.

Was just fishin around...

Post Edited (Canada Mark) : 1/25/2014 8:16:45 PM (GMT-7)