Fungal Diversity and effect on bacterial composition after antibiotic use

We saw an integrated dr last week for the first time. He thinks there is a high chance my son has candida as he scored highly on a specific set of questions - one of which was how often have you had antibiotics in your life? He is trying a no-sugar diet (hard!) with probiotics, a herb to kill the candida and others to support liver, kidneys and pancreas. So we will see......... anything is worth a go.......

Here is another paper.

I am starting to wonder if over the past 100 years or so, the research has concentrated on bacteria way too much

and even today.

We know that antibiotics reduce the bacteria,the bacteria keep the fungus in check.

If the fungus get out of hand then,it makes things worse.

There is not that much out there,but will keep digging.

Old Mike

http://ac.els-cdn.com/S1931312812001710/1-s2.0-S1931312812001710-main.pdf?_tid=43194bfc-8a87-11e3-bdf9-00000aab0f01&acdnat=1391180110_d7fccf149116509d44a7e09d4ff528fe

This may have been posted before but should go with this.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432565/

confounding info

http://link.springer.com/article/10.1186%2F1471-230X-12-33#page-1

I am about to get confused.

http://www.sciencedirect.com/science/article/pii/S1043466613005322

might be redundant in the gut

http://iai.asm.org/content/80/12/4216.full

here is an interesting one just click on I agree and download the pdf.

Seems a lot of fungi can come from the oral cavity to the gut

not quite sure what the hell they are saying though. Also fungus bounces back after antifungal treatment.

http://www.medscimonit.com/download/index/idArt/881193

interesting actual UC in humans treated with antifungals

http://www.ncbi.nlm.nih.gov/pubmed/17203803

Post Edited (Old Mike) : 1/31/2014 10:23:06 AM (GMT-7)

What type of doctor do you see for your diflucan? How much are you taking? I live in such a rural area I have to drive forever for a NP doc

What I find interesting is that if you look at IBD as whole - All the studies, and really focus in on all the cellular immune responses what seems to pop out is a reaction not to anything specific, but a variety of things... in other words there is a response that activates or provokes an immune reaction to bacteria, fungus and parasites.

More so an innate response in UC and adaptive response in Crohns.

In thinking about this the last while I think this just ties back to a defective mucus barrier. Further, since there is characteristics of both innate and adaptive in both IBD diseases, it seems to me like either the immune system in overwhelmed due to a barrier problem perhaps - or more likely (in my opinion) simply confused, in other words it can't quite figure out just how to fix itself or how to deal with what's offending it, so it's calling on all responses.

As well, some of the immune cells involved are normally "reserved" for some pretty serious offenders. So I just think this further points to a mucus defect.

Have gone through all 20 pages on pubmed on fungus colitis, I have added a few more things to the
above.
Where this leaves us hard to say.
Old Mike

Yes- that's what I'm thinking as well - fix the barrier. This gives the immune system a little help by reducing the load (if a barrier issue is even the problem).

In any case that was my most recent approach which seems to be proving to be quite successful. Or more so than any thing else I have tried (meds/natural)

I'd like to follow up on some of the mucus barrier drugs out there, but can't quite remember what they all were - there was the pig mucus supplement one. OM maybe you can remember.

I believe it was a company that was testing actual pig mucus.

Same thing for the last few months:

Pred - double length course (hoping to thicken mucus)
Immuran - induce macrophage apoptois
Woo/Thyme - bacterial/fungal and induce cellular apoptosis
RS (Potato Starch) - easier to digest for butyrate production etc.

The idea being that maybe there is an overload of bacteria etc, and since i'm crohns-colitis the possibility they are AIEC type so they hide out and multiply inside macrophages.

So thicken up things with the mucus if possible, induce cellualr death to hopefully release the bacteria and let the immune system get at them, and hopefuly over time reduce the load and start to heal.

I was out of options so though what the heck - makes a bit of sense at least, haha.

I've had more perfect one wipe trophy poops in the last two or three weeks then I have ever had in the last 10 years. Its working (from a symptom) point of view far better than Remicade ever did.

In fact yesterday I was like wow, now I actually do remember what a normal poop was like. Been off Pred for a few months and doing quite well. Normally I am pred dependent.