Tuff read,but interesting.
Mostly discusses ROS,but DSS and NAC in WT mice made the colitis worse.
NAC also thins mucus.
Old Mike
try this link
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095332
Then again this human trial indicates it helps.
http://www.wjgnet.com/1007-9327/14/2851.pdf
protease inhibitors
http://www.ncbi.nlm.nih.gov/pubmed/8358131
http://www.ncbi.nlm.nih.gov/pubmed/17551835
It now occurs to me that if people can be put into remission just with the camostat or BBI,there are implications.
Excess protease can come from digestive enzymes that are not deactivated, bacteria, and immune cells.
The proteases are dissolving the mucus and I guess any part of the colon they can contact,UC people also have excess
proteases in stools.
Implications:
By inhibiting protease/keeping the mucus intact you can go into remission, regardless if UC is autoimmune,or biofilms or bacteria are driving the inflammation.
We have an, alpha 1-proteinase inhibitor system which can become overwhelmed and allow protease to attack the mucus and tissue.
this is a way to perhaps accomplish the same thing without taking protease inhibitors.
http://www.ncbi.nlm.nih.gov/pubmed/2833080
sulfhydryl blockers UC mouse model
http://www.ncbi.nlm.nih.gov/pubmed/9165366
alkylating agents in diet, they might act as sulfhydryl blockers
http://www.ncbi.nlm.nih.gov/pubmed/3366423
reduces colon mucus hydrophobicity
http://www.ncbi.nlm.nih.gov/pubmed/17693944
Post Edited (Old Mike) : 1/15/2015 9:08:57 AM (GMT-7)