Mesalamine Enema Progress

So I added a mesalamine enema to my nightly regimen Monday evening, and I think I've gotten worse. I wasn't bleeding for 2 weeks until I started the enemas, and now I am. It's only in the morning, and it's formed around the stools, not straight blood in the toilet. I feel like I should not be feeling worse after starting the enemas. Is it possible I'm not reacting to the mesalamine anymore? I've only been able to hold them in for 3 hours at a time, and the inflammation gets worse as the night goes on. I hadn't felt this type of inflammation at night in a few weeks.

Should I stay the course? Or ask my GI about trying the steroid enemas instead?

I am seeing a different GI Monday and hopefully going in a different direction. I've lost over 20 lbs during this flare and need to get out of it sooner rather than later, before I get even worse.

Currently on a prednisone taper from 40mg. I feel pretty good the 3-4 hours after I take pred each time, but still no regular BMs. Perhaps we didn't hit the flare hard enough originally when we started at 20mg?

When did you start pred? So weird for him to say to hold the enema for three hours. Most of us just use it before bed and hold it all through the night if possible. It's not possible for me haha.

I ended up stopping the enemas because I was significantly worse than when I started them. The blood was then gone almost immediately. I have no idea if those were the direct cause of getting worse, but it didn't make sense to continue at this time.

I'm holding out til Monday when I meet with a new GI. I really need to get out of this flare because my weight loss is so significant right now, even on prednisone. I wouldn't be surprised if I was admitted for a couple days to get some nutrition back and then start a new treatment plan.