'Normal' bacteria vital for keeping intestinal lining intact

Wow! I'm very impressed.

What is probiotics in the form of IPA-producing bacteria? I tried a search but couldn't find anything. Is it certain strains or all probiotic bacteria?

Thanks for posting Kevin. The wiki link says that it is involved in sweat and B12 production. I am low on both.

Used in cheese making? Seems you can purchase a strain of it from cheese making suppliers..
www.cheesemaking.com/store/p/147-Proprionic-Shermanii-Swiss-1-packet.html

Holes in the colon cures by bacteria that causes the holes in cheese, certainly sounds counter-intuitive!

"The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer’s disease. Indole-3-propionic acid (IPA, OXIGON™) is a potent anti-oxidant devoid of pro-oxidant activity. IPA has been demonstrated to be an inhibitor of beta-amyloid fibril formation and to be a potent neuroprotectant against a variety of oxidotoxins. This review will summarize the known properties of IPA and outline the rationale behind its selection as a potential disease-modifying therapy for Alzheimer’s disease."

link.springer.com/article/10.1007%2Fs12031-002-0036-0


Indole-3-propionic acid (IPA), a deamination product of tryptophan, with a structure similar to that of melatonin, is present in biological fluids and is an effective free radical scavenger.

www.ncbi.nlm.nih.gov/pubmed/11255233

IPA is produced by deamination of L-tryptophan by commensal bacteria in human and animal intestines (45), although its production by other tissues has not been systematically investigated.

www.jbc.org/content/274/31/21937.full

Apparently its not to be eaten..but it can be purchased

www.caissonlabs.com/product-I009-500GM-Indole-3-propionic-Acid-(IPA).php?id=419

Colonization can be established with a single bacterium

Clostridium Sporogenes

books.google.com/books?id=UekxAwAAQBAJ&pg=PA21&lpg=PA21&dq=Indole-3-propionic+acid+probiotic&source=bl&ots=n1-vWrWlfn&sig=oyVUdWNbJksoOhX0BHn27Q0Hw8w&hl=en&sa=X&ei=RfjbU4iZF8me8gHBv4CwAg&ved=0CEgQ6AEwAw#v=onepage&q=Indole-3-propionic%20acid%20probiotic&f=false

Post Edited (aguywithuc) : 8/1/2014 2:26:59 PM (GMT-6)

Here is a clue.Seems we found the same study London and aguy,we are all looking at the same info.

OM

http://www.pnas.org/content/106/10/3698.full

reference 27

http://link.springer.com/article/10.1007/s002489900020#page-1

seems tryptophan is the precursor,then we get into the 5htp and serotonin mess.

looks like dried egg white has the most

http://en.wikipedia.org/wiki/Tryptophan

Post Edited (Old Mike) : 8/1/2014 2:55:52 PM (GMT-6)

www.abpl.co.in/Probiotics-PreProbiotics-Product.htm

Forgot to mention this company makes probiotics containing Clostidium (Though a different strain) their brand name Bifilac - I believe it was Path that pointed them out and mentioned a friend having/seeing success.

I was looking for Clostridium probiotics a month or two ago as a possible alternative to FT. Have not found another source yet.

Post Edited (Canada Mark) : 8/1/2014 3:59:46 PM (GMT-6)

Here is what they (amongst other bacteria) do with l-tryptophan. Or the pathway that converts it to the indole they refer to.
www.biocyc.org/META/new-image?type=PATHWAY&object=TRPKYNCAT-PWY&detail-level=3&ENZORG=TAX-1509

Sort of gives a thumbs up to some of the other lacto bacteria and such that seem to show anti-inflammatory properties.

I hope the link above works - It's pretty handy has you can go back to the main thing and choose say Folate or well whatever you are curious about.

The link is from a school class actually.

Not that it really shows anything or helps much with this topic, but it might interest some.


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NOTE: On the link you can go to "search" in the green menu bar and click "search pathways", then click "list of all pathways button" and this will bring up all known metabolic pathways for bacteria etc - Or you can click the button for "search/filter" by organism - in this case you would click on Firmicutes and then Clostridia etc etc to get to the strain and then you can see what other Amino Acids it has the capability of using as an energy source etc.

Post Edited (Canada Mark) : 8/1/2014 6:44:12 PM (GMT-6)

So does this mean VSL#3DS could be helpful ?

Somebody said...
In vitro, VSL#3 was found to selectively inhibit activation-induced secretion of the T-cell chemokine interferon-inducible protein (IP)-10 in IEC. Cell wall-associated proteins of VSL#3-derived Lactobacillus casei (L. casei) were identified to be the active anti-inflammatory component of VSL#3. Mechanistically, L. casei did not impair initial IP-10 protein production, but induced posttranslational degradation of IP-10 in IEC. Feeding studies in tumor necrosis factor (TNF)Delta ARE/+ mice, a mouse model for experimental ileitis, revealed that neither VSL#3 nor L. casei is capable of reducing ileal inflammation.

www.ncbi.nlm.nih.gov/pubmed/20562631