Exogenous alkaline phosphatase for the treatment of patients with moderate to severe ulcerative coli

I remember reading somewhere that a guy treated his UC with olive oil, and myself have been wondering about coconut oil.

Not sure what to do after glancing at these. Unfortunately, I'm flaring now. Dreading going to work today :(

Old Mike

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Posted 8/28/2014 12:30 PM (GMT 0)

I tried the olive oil approach,did not work for me,might have even caused more problems.

But I am also concerned about excess phosphate in our diets today.

From an industrial standpoint, whenever we added phosphate to our water emulsions,

the bacteria went crazy,and were difficult if not impossible to control even with powerful industrial

biocides.

Will have to look into a phosphate limiting diet,and its effects on bacterial LPS/endotoxin,if

there is any info. LPS contains phosphorous.

Old Mike

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Posted 8/30/2014 12:11 PM (GMT 0)

Here is a cached version cannot get direct link

This is on oral administration of alkaline phosphatase.

They make a profound statement,that there is little in the colon/rectum,compared to the ileum.

Has to be generated by mRNA, and the implication is that it is not necessary in the colon to detoxify endotoxin.

It is found in the ulcers as compared to near by non inflamed tissue.

That leads to further speculation of the implication on my part.

Namely that the body evolved so that the mucus barrier is more than sufficient to prevent bacteria penetration

and endotoxin release into the colon mucosa, and it is not really worried about it,but has a back up just in case.

This further implies to me that something rather drastic has to take place to allow for the bacterial penetration

past the mucus barrier,and colitis to be induced.

Also iAP found in stool.probably I guess mixed in from the ileum,perhaps why not necessary to be made

in the colon. So if you have low iAP from the small intestine what are the implications for UC.

Might explain why oral iAP can induce remission.

But of course there is no dam supplement of iAP.

Old Mike

http://webcache.googleusercontent.com/search?q=cache:yHJS8n6zxsYJ:dissertations.ub.rug.nl/FILES/faculties/science/2007/a.tuin/c6.pdf+&cd=9&hl=en&ct=clnk&gl=us

if you want in pdf form just search the title

from small intestine if stool but 50% reduced in active UC

http://www.researchgate.net/publication/15775175_Activity_of_small_intestine_alkaline_phosphatase_in_the_feces_in_chronic_intestinal_diseases

Post Edited (Old Mike) : 8/30/2014 8:11:08 AM (GMT-6)

London Lurker

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Posted 8/30/2014 2:32 PM (GMT 0)

I'm confused, I'd been under the impression that high alk phos in the body means that your liver is damaged?

Old Mike

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Posted 8/30/2014 2:43 PM (GMT 0)

Talking about intestinal alkaline phosphate,not liver. iAP.
This is the stuff that detoxifies bacterial endotoxin/LPS in the intestine.
OM

http://www.ncbi.nlm.nih.gov/pubmed/23860646

oral vitamin K1 and mk4 induce iAP

http://www.ncbi.nlm.nih.gov/pubmed/22041909

Post Edited (Old Mike) : 8/30/2014 9:30:40 AM (GMT-6)

London Lurker

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Posted 8/30/2014 2:53 PM (GMT 0)

Thanks O M. I just came across this about what can raise AP in the liver "Eating a fatty meal if you have blood type O or B" - wonder if blood type would influence bowel levels as well?

Old Mike

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Posted 8/30/2014 3:17 PM (GMT 0)

Yes I read something about blood type also,type o which I am you are supposed to have 4 times as much as
some other types. But who knows about iAP for sure and blood type,possible junk science.

After a fatty meal endotoxins can get to the liver,where AP can detoxify,I believe.
OM

Post Edited (Old Mike) : 8/30/2014 9:20:11 AM (GMT-6)

Old Mike

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Posted 8/30/2014 4:36 PM (GMT 0)

iAP has never been on my radar until this week,seem rather important. Cant believe I never ran across it before.
Comes from the brush borders in small intestine found in feces,with UC 50% low.
Detoxifies endotoxin/LPS, unmasks bacteria hiding behind LPS,Iga need to be specific but needs to be able
to read the bacteria,but cannot if masked by LPS.
Not normally made in colon,but found in ulcers,made from mRNA.
Phenylalanine can suppress,that is found in many protein foods,inorganic phosphate can suppress.
Oral iAP can induce remission in humans,no supplement that I can find.
But we can have some control to up regulate with zinc, and oral vitamin K's,possibly onion,butyrate,glycine.
If brush borders are damaged by celiac then you make less.
That's my bottom line so far.
Old Mike

human uc study

http://www.ncbi.nlm.nih.gov/pubmed/19885903

what a pain tnf blocks butyrate induction of iAP, this shows why oral alkaline phosphatase might work

tnf has got to go somehow other than biologics, Wellbutrin

http://www.ncbi.nlm.nih.gov/pubmed/17233117

Post Edited (Old Mike) : 8/31/2014 6:23:57 AM (GMT-6)

Old Mike

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Posted 9/11/2014 3:33 PM (GMT 0)

Potato starch,or organic bound phospahte increases,inorganic phosphate decreases iAP. High fat increases iAP.
There is a lot of added inorganic phosphate,in commercial breads,cream,half and half. Medium chain fat such as coconut might

work better.

iAP is very important to gut health,and it is something you can control somewhat,also black pepper increases.

And yes I am still working on this,and if it works as a med in human trials for UC,where is it.

Old Mike
http://www.ncbi.nlm.nih.gov/pubmed/20579526

http://www.ncbi.nlm.nih.gov/pubmed/2398418

http://www.ncbi.nlm.nih.gov/pubmed/7467486

oh great iron fortification reduces it,but we could also control that,flour and cereals have all been fortified

for a long time,I even have a thread somewhere on iron in water causing a UC increase

http://www.ncbi.nlm.nih.gov/pubmed/20020942

tnf will inhibit,not good

http://www.ncbi.nlm.nih.gov/pubmed/17233117

spices onion and coriander/cilantro but believe they used the seeds in the study

http://icmr.nic.in/ijmr/2004/0501.pdf

Post Edited (Old Mike) : 9/13/2014 1:59:27 PM (GMT-6)

DanthaMan

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Posted 9/11/2014 5:17 PM (GMT 0)

interesting I have noticed that commercial breads mess me up and I have never been able to take iron supplements..wonder if this is why.

Pork does me well and its high in fat.

Old Mike

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Posted 9/11/2014 6:44 PM (GMT 0)

Iron also creates other oxidation reactions in the gut,besides messing with alkaline phosphatase.
I often wonder why the rectum is so hard to heal, perhaps it is the leaking blood which contains iron.
Excess iron will also tend to grow iron loving bacteria.
Also iron is a limiting nutrient to all kinds of bacteria,when there is infection the body releases lactoferrin which chelates iron.
But a lot of bugs can circumvent this.
OM

DanthaMan

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Posted 9/15/2014 2:50 PM (GMT 0)

So how about a complete turnaround in less than a weeks time. Started taking Sodium Butyrate 2 pills twice a day along with Seacure 2 pills twice a day. I did that for a few days then read this thread www.healingwell.com/community/default.aspx?f=38&m=2755997 and started taking my OoO directly under the tongue. Normally I would chase it with my Psyllium seed in the morning but now I space it out. Then reading this thread I added the Vitamin K combo pill. Saturday I went 23 hours without going to the bathroom. Yesterday was good about 6 hours between going maybe longer.

OM not sure if this is going to make sense or not but I noticed that when I didn't feel well this last time my teeth didn't feel clean. No matter how much I brush them the back of my front two teeth feel like they weren't brushed. As soon as I started this last protocol they feel clean. I remember you saying something about bacteria in the mouth and IBD, wonder if this is why OoO works well?

Post Edited (DanthaMan) : 9/15/2014 9:19:40 AM (GMT-6)

Old Mike

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Posted 9/15/2014 3:43 PM (GMT 0)

Dantha: Sounds like you are on the right track.
Oral bacteria pathogens have been found in the colons of UC people,I have a thread somewhere I think.
Oregano oil might kill them not sure,also if you take the oil under the tongue it will be absorbed and bypass and digestion
of it in the gut. How much are you taking a day.
OM

aguywithuc

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Posted 9/15/2014 4:59 PM (GMT 0)

Unclear what action this research suggests we take ?

Old Mike

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Posted 9/15/2014 6:40 PM (GMT 0)

Aguy: If you are referring to the iAP research,need to increase it.

From diet,low inorganic phosphate,low iron,perhaps in the form of fortified foods,but not sure on that one,red meat contains a lot.

But I have been on a no red meat diet,which had no effect on me. Inorganic phosphate and iron inhibit as does tnf.

I have just started to take coriander ground seeds,and will eat some raw onion,but not too much,dont want to feed bacteria too much FODMAP.

Coriander and onion,up regulate iAP, at least in rats.

Since there is no iAP supplement that we can buy, I am making an attempt to upregulate, my own.

curcumin

http://medicalxpress.com/news/2014-09-oral-curcumin-gut-function.html

Post Edited (Old Mike) : 9/25/2014 7:44:19 PM (GMT-6)

DanthaMan

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Posted 9/15/2014 7:23 PM (GMT 0)

OM: I take 3-4 drops in the morning, leave it under the tongue as long as I can normally about 30 seconds, then add water and swish it around then swallow it. It will put some hair on your chest thats for sure.

aguywithuc

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Posted 9/15/2014 7:41 PM (GMT 0)

Old Mike said...
Aguy: If you are referring to the iAP research,need to increase it.From diet,low inorganic phosphate,low iron,perhaps in the form of fortified foods,but not sure on that one,red meat contains a lot.
But I have been on a no red meat diet,which had no effect on me. Inorganic phosphate and iron inhibit as does tnf.
I have just started to take coriander ground seeds,and will eat some raw onion,but not too much,dont want to feed bacteria too much FODMAP.
Coriander and onion,up regulate iAP, at least in rats.
Since there is no iAP supplement that we can buy, I am making an attempt to upregulate, my own.
OM

Thanks.

Unfortunately I am always low in RBC so consuming iron any way I can.
Low homocysteine discovery over the weekend was a shock and am able to take things I bought for that.

Keep us posted on your progress with this.

DanthaMan

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Posted 9/24/2014 2:04 PM (GMT 0)

Well spoke too soon, back to stomach gurgling..teeth feeling nasty. Thinking back to my diet I had spinach a few times the week before as well as sunflower seeds as well. I'm really tired after 12 years of dealing with this DD.

Canada Mark

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Posted 9/24/2014 11:12 PM (GMT 0)

DanthaMan said...
I'm really tired after 12 years of dealing with this DD.

Me to man... me to... Same timeframe. Though luck's been on my side for about the last year thankfully and for the first time I'm in a long lasting remission of sorts.. Still though, the prior 12 years got to me.

sweety5

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Posted 9/26/2014 12:25 AM (GMT 0)

I thought of jump in and thank Old Mike for doing his own research and updating us with valuable information. Really appreaciate it.

London Lurker

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Posted 9/26/2014 12:07 PM (GMT 0)

Interesting how these things you mention OM, the turmeric, coriander seed, onion would feature heavily in a traditional Indian diet and, where I live, where there is a large immigrant Indian population, the incidence of 2nd generation and beyond developing IBD is growing fast, making it as common as it is in the Ashkenazy Jewish heritage population.

Old Mike

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Posted 9/26/2014 12:09 PM (GMT 0)

Might have something to do with my other new thread,on prenatal vitamins, methyl donors,who knows.

I might suspect the mothers of 2nd generation kids,are getting these across the pond as well as here.

Has the diet perhaps changed somewhat to include meat,or lots of veggie protein.

Phenylalanine inhibits iAP,found in protein foods.

My wife perhaps should have IBD but does not,she quite smoking and also drinks diet pepsi.

.

OM

Post Edited (Old Mike) : 9/26/2014 9:06:25 AM (GMT-6)

Old Mike

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Posted 4/19/2016 7:59 PM (GMT 0)

I continue to look at this.
Inorganic phosphate is everywhere in the diet, never tried a low inorganic phosphate diet,or is something

like the SCD, or paleo really one in disguise. But phenylanaline also inhibits, which is high in meat.
I am still looking for the overlooked. We know IAP oral works in people, but no supplement,
only way around is to make more of your own if possible,or lower inhibition.
The reason I have interest in this is IAP detoxifies/kills bacteria with LPS before it can get
to the immune system,plus it does a lot of other stuff like promotes good bacteria.

OM

mechanism of phosphate inhibition

http://biology.stackexchange.com/questions/7304/how-does-inorganic-phosphate-inhibit-alkaline-phosphatase

here are some hidden sources, also check you bread loaf
https://www.davita.com/kidney-disease/diet-and-nutrition/diet-basics/hidden-phosphorus-in-your-diet-and-how-to-control-it/e/5322

binders I guess calcium is the easiest way to go
https://en.wikipedia.org/wiki/Phosphate_binder

vitamin D can up regulate IAP
huge problem with inorganic phosphate
below it keeps bacteria from getting to the lymph nodes which may help to keep the immune
system from getting overly excited.

Old Mike

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Posted 4/20/2016 12:51 PM (GMT 0)

Phenylalanine inhibits IAP.

What the heck is it doing in Apriso.

http://www.aprisorx.com/

here might be a clue why threonine helps some with UC

mechanism for reduction unknown at this time

http://journals.lww.com/jpgn/Fulltext/2003/01000/Dietary_Threonine_Reduces_Plasma_Phenylalanine.7.aspx

Post Edited (Old Mike) : 4/20/2016 10:26:28 AM (GMT-6)

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