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The fecal transplant pill and low dose Nalgtrexone

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Ulcerative Colitis
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Posted 10/15/2014 4:53 PM (GMT 0)
Ok,,,read in the Washington Post about the Fecal Transplant Pill,,,,In tests done,,,using 20 people, 18 of them got better....but it was mostly people with C diff....I was hoping it was for colitis,,,
Also,,,my son asked his gastro doctor about the low dose naltrexone and he nixed the idea. Said he wasn't sure about it,,and it was an opiat ?? so,,,now my son is depressed...He still wants to try it and will ask his dermatologist who is trying to treat his pyderma gangrenosum...(caused by his screwed up immune system) if he would prescribe it....He has all these awful sores all over both arms that won't heal...terri ble...
Posted 10/15/2014 7:39 PM (GMT 0)
You can look up the member InSoFla using the following link and email her at the address in her member profile. She doesn't post here anymore but is the leading expert here on LDN and claims she can help people get prescriptions. Don't bet the farm that this will be a magical cure though. Sometimes it works. Most of the time it doesn't.

www.healingwell.com/community/default.aspx?f=38&m=2339658
Posted 10/15/2014 7:49 PM (GMT 0)
I was actually able to get my gastro to give me a script for LDN - I spent about 14 months on it. It did help (especially when combined with Uceris), but not enough - I'm no longer taking it for that reason. I don't think my gastro would give just any patient a script - at the time, I had no options that weren't a clinical trial or non-FDA approved med (or surgery), and I did my research and came to him with it (read the preliminary studies - it doesn't hurt that I'm a research scientist). Even then, he made me agree to max-out the timing/dosage of the Remicade that wasn't working (and never did work) before switching to LDN.

LDN is not an opiate - it is an opiate receptor antagonist, meaning it binds to opiate receptors (and blocks opiates from binding to them, which is why higher doses of naltrexone have been used to treat opiate addiction). The idea is that by temporarily blocking these receptors, the body responds by increasing production of endorphins (and other related compounds) which acts to improve healing/modulate immune response.

Good luck.
Posted 10/15/2014 8:37 PM (GMT 0)
The study was published in Journal of American Medical Association, but it was not "mostly" for people with c-diff. It was "entirely" for people with c-diff.

jama.jamanetwork.com/article.aspx?articleid=1916296

Cure rate was similar to FMT enemas, with about 90% cured after 1 or 2 doses.

But this was a thing used in preliminary research to assess safty and efficacy. It is nowhere near being available for prescription. And what is going to happen is that the key strains are going to be isolated, and improved probiotics (poop free) are going to be developed.

There will almost certainly not be widely used poop pills. There will surely be rapid development of the probiotic therapies. Hopefully for UC too.
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