Does splitting your pred dose make a difference?

Not sure if it makes a difference but when I was on 40mg/pred I do remember taking 2 in the morning and 2 at night at first, I think I did change it to all morning because I was having bad Insomnia and my GI recommended it.

I think it all depends on what works for you - if you want to, split it up and see how it works out. if that doesn't work, go back to taking it all at once. I'm in a similar position to you right now, taking 40mgs a day but not seeing the relief I want - i feel great until 5-6pm and then the symptoms return. I may do it myself especially since things seem to get worse for me later on in the day. Been on 40mgs a week as well.

Good luck, hope you won't have to stay on pred for too long!

Personally I've never been a fan of splitting pred, I've always taken it very first thing in the morning as it's always been prescribed to me that way to avoid any insomnia issues...and for me it wouldn't "wear off" as the day/night went on.

To each their own though as I'm sure some swear by splitting their pred.

The experts say to take it all at once in the morning with food. Some claim it works better to split it up.

Around the 3'rd or 4'th time taking pred I started trying one full week of all 8 at once, then I would start to split it - 4 tablets in the morning with breakfast and four tablets at lunch. That way I still could somewhat to get sleep at nights.

Work's pretty good this way I find. Easier on the stomach and it's only a few hours delay between the two doses.

You could perhaps try something like this versus splitting morning and evening.

One more thing. If it's taking weeks for Pred to have an effect, you should talk to your doctor about a higher dose. 40 mg isn't that high and a few days at 60 mg, then a few days at 50, then back to 40 may help. That's what I did last time I was on it.

we only go on the devil drug cuz we wanna get better quick - I agree that if 40 isn't getting there quick enough, a step up to 60 should help - just stay there long enough to get the job done then get the hell back down -

Be careful with prednisone tapering, most importantly, don't start it too soon. Stay at 40mgs until your symptoms improve considerably. You need to be 90 plus percent healed BEFORE you are off of pred entirely, otherwise your flare symptoms will return. And it sounds like you are not seeing improvements yet. So take that taper schedule and forget about it. Instead, watch your symptoms and listen to your body. Reduce pred slowly as you are healing and not until then.

My GI had me split my pred dose up quite a bit, because he said it's much less suppressive to the adrenal glands to do so (pred suppresses the production of cortisol). Your body produces the most cortisol in the morning, so if you take the entire dose in the morning, your suppressing your adrenal gland quite a bit more than if you split the dose. So when I was on 40 mg, I took 10 mg 4 times a day (breakfast, lunch, dinner, and bedtime). As I tapered, I'd drop the last dose of the day, so at 30 mg I was taking it at breakfast, lunch, and dinner, at 20 mg I was taking it at breakfast and lunch.

A lot of people on here criticized this plan, but I have to say that I was able to quite easily taper off, even though I dropped 10 mg at a time. I went 40 - 30 - 20 - 10 - 10 every other day - off. And yes, I realize that everyone is different, but it was very successful more me, I think because my body didn't have as much trouble producing cortisol on its own again.

Well I have no intention of tapering until I feel comfortable to do so. And I don't yet.