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Ulcerative Colitis
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Posted 11/7/2014 3:00 PM (GMT 0)
Has anyone heard that this medication is more likely to work for people who don't respond to tnf blockers?

I have heard this and I would think since a lot of people respond to tnf blockers, the percent of people who would respond to this would be low.
Posted 11/7/2014 4:35 PM (GMT 0)
Not sure if that is accurate or not. Assuming it is though I think Remicade has the best success rate at between 33% and 40% (if I remember right) so that would mean that 60% to 67% don't respond well to it, which would maybe be good news for Entyvio.
Posted 11/7/2014 4:46 PM (GMT 0)
Entvyio works different than tnf-alpha blockers. Not sure that it works better for those who didn't respond to anti-tnf though. I remember the clinical studies for entvyio said a more than expected amount of the participants had previously failed tnf-alpha treatments. So there is hope it'll work for those that other treatments had failed. Haven't seen numbers stating odds though.
Posted 11/7/2014 5:57 PM (GMT 0)
But does failed mean nonresponsive to antiTNF or does it mean it works and then failed?

I think the response rate to Remicade is higher, closer to 50-60%? I wonder where we can find these statistics...
Posted 11/7/2014 6:12 PM (GMT 0)
I think failed can either mean it didn't work ever or it worked for a time frame and then stopped working.

Humira never worked for me at all and Remicade did for about 6 months. When filing insurance to start Entyvio it was marked that I had failed 2 biologics.
Posted 11/7/2014 6:33 PM (GMT 0)
Remicade response rate is 44-45%

aboutcolitis.com/remicade-ulcerative-colitis-treatment/

link didn't seem to work but here is the paragraph:
Remicade Ulcerative Colitis Treatment?

Remicade, or Inflixmab to be more precise, binds to the TNF, which is regarded as more similar to the Th1 cytokines. Tests by Paul Rutgeerts and William Sandborn in 2005 have overturned earlier opinion regarding limited efficacy of the drug for UC, by showing in two clinical trials that Remicade does indeed have a higher success rate than placebo medication. Indeed, with remicade ulcerative colitis patients showed a response rate of 44-45% when treated for a year, as opposed to 21% for placebo medication.

I still can't believe the high success rates for placebos. I wonder if they work by decreasing stress levels?
Posted 11/7/2014 6:40 PM (GMT 0)
Thanks Gary, that's interesting. My GI said unresponsive people have the best chance of success. She didn't say "failed". I wonder where this info comes from - i would imagine the trial results for entyvio...
Posted 11/8/2014 2:41 AM (GMT 0)
I have stared Entyvio. I have just completed my second treatment. That being said I am not able to say how it compares to other treatments. Well I can say for me it is significantly better than Immuran. Immuran is not good for me.

Is Entyvio better than Humaria or Simponi or...? Data seems to suggest yes but how it works for you is all that really matters.

Now this leads me to the point I want to make. To me Remicade is just not a viable/reasonable treatment. The infusion takes ~8 hours. Please correct me if I am wrong. That amount of time is simply not reasonable. For me that would be much more impactful than my symptoms.
Posted 11/8/2014 3:38 AM (GMT 0)
Remi treatments take at most 3 hours.... No one could do an 8 hour infusion
Posted 11/8/2014 10:30 AM (GMT 0)
Remicade infusions take a few hours. Not eight hours. Maybe three or four at the most. I don't think the success rate with entyvio is better than the others, I think it's method of working is different so it may help people when the other meds do not work. It almost sounded like only one or the other would work according to my gi.
Posted 11/8/2014 12:48 PM (GMT 0)
When I was on Remicade my infusions took no more than 3 hrs. Sometimes a few minutes less. I did not respond to Remicade and stopped after 6 treatments (including 3 double dose.) I've had my 2nd Entyvio treatment two weeks ago, and have definitely seen improvement. I've been able to start tapering off of Prednisone with no problems so far. I go for treatment number 3 on 11/21.
Posted 11/8/2014 3:11 PM (GMT 0)
I would ask your gi for clarification. If he/she has read such things then I would want sources. Seems no on here has heard it...

Ive heard low 60 percent response rate for remicade. Entvyio was close, maybe a few percent points lower.
Posted 11/8/2014 3:49 PM (GMT 0)
For me Entyvio is much better. Not the sick feeling and little response from Remi. no swelling like simponi. While both worked well to start, neither were long term for me. Eight weeks on entyvio and progress is slow but progress. Do not have stats on effectiveness of any of the meds... but I am glad entyvio came long for us who failed TNF blockers. I was very guarded in progressing to enytyvio but so glad I did, best response in 3 years. GI doctor say it also safer than the other meds I have tried. Time will tell. Just happy something works for now until another discovery is made
Posted 11/9/2014 3:23 AM (GMT 0)
I too am on Entyvio. While I like my GI I am the one that brought up Entyvio. I am the first patient the practice has put on Entyvio.

From my research (limited as it is) I feel like Entyvio is the best, safest treatment path. There maybe something that works better for you. You need to start someplace and see how you respond to the drugs.

The key is not to be afraid to step up and make noise.
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