Posted 7/6/2015 7:45 PM (GMT 0)
The depression sessions talked about SSRI's and serotonin too. People who have UC are probably deficient in some of the B vitamins, which are needed to make serotonin. Add on to that, some people may have trouble converting folic acid into folate (which is needed to make serotonin) due to a common genetic defeat with one of the enzymes needed in the conversion process. Thus, getting enough folate is very important in combating depression, and getting enough folate from eating green leafy vegetables (such as spinach) is especially important.
This is what they had to say about SSRI's:
Short-term: SSRI's work by keeping serotonin outside the nerve cells, in others words, they inhibit the re-uptake of serotonin. The more serotonin floating around outside the cells, the happier and less anxious your mood will be. That's the short-term effect (although there is also the placebo effect, which is supposed to be very high with SSRI's).
Long-term: Serotonin that is not in the cells gets broken down by enzymes. As a result, the level of serotonin outside the cells gradually declines over months and years, causing the effects of SSRI's to gradually diminish. Doctors will often recommend increasing your dosage or adding another anti-depressant when this happens.
Getting Off SSRI's: When you taper off SSRI's, it takes only two to three weeks for the SSRI's to get out of your body. However, it takes a long time for your body to start increasing its production of serotonin to raise the level of serotonin back to normal levels. Plus, the inhibited receptors have trouble working again. The result is that you become increasingly depressed and anxious. Depending on how long you've been on SSRI's and the dosage you were on, it could take anywhere from four months to four years for your body's production of serotonin and uptake of serotonin to be back to normal levels. For some people, they never get back to normal. This is why many have trouble getting off SSRI's.