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Medication Change & faecal calprotectin test

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Ulcerative Colitis
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Posted 8/27/2015 6:00 AM (GMT 0)
Hi there,

I have a question for all you UC sufferers on here that have or are on azathioprine.
My new GI has advised that he would like to do a faecal calprotectin test and if high place me on azathioprine. I am looking very much forward to a medication change as i have NEVER been in remission longer that 3 months and at the moment i am flaring and this has been the hardest to kick as i am not using steroids for flares any longer and currently using asacol 2g enema (night) & pentasa suppositories. I am not experiencing frequency ATM as i took a course of flagyl i had in my cupboard and now I'm not running to the loo all day however i am having very strange skinny, oily BM's with lots of mucous and blood.

I would like to hear from this who have had positive and negative results.
Posted 8/27/2015 6:19 AM (GMT 0)
Have you ever had C-Diff? AZA usually takes at least two months before it starts working.
Posted 8/27/2015 6:31 AM (GMT 0)
C-diff has never been formerly diagnosed however i have been on Flagyl before for suspected C-diff, my gp put me on it as a precaution. Last time i took it i was nearly 100% better in 2 days? This time i just took a course of flagyl i had that i filled from the repeat and really has only decreased the urgency. I don't think i have c-diff but who would know? I asked my GP if we should do a stool test and she said my symptoms were not classic of C-Diff.
Posted 8/27/2015 1:48 PM (GMT 0)
You should take some mega dose probiotics of about 50 billion CFU's or more per day. If you find the right one it will not only help your UC but keep C-Diff and other pathogens at bay. I doubt Flagyl would have done much for C-Diff in just two days time but you may have had some other pathogen where it worked that fast. Antibiotics can often make UC worse unless your problem is from a pathogen.

I've never taken AZA myself but just about anyone here who takes it doesn't see much benefit for at least two months so you are going to have to do some kind of treatment until it kicks in. It worries me about taking AZA with your Netrophil but the doctor must know what he's doing there, I hope.
Posted 8/27/2015 2:36 PM (GMT 0)
Hi garylouisville,

Thank you for the insight yeah my worry is that AZA takes a while to kick in, i will try the probiotics for sure. The AZA and the netrophils was the first thing that sprung to mind as it is clearly a high point of concern. Im thinking of changing GI's yet again because i just feel like I'm being treated like a crash test dummy again. I mean his still got me on 3 doses of Salafalk daily and apparently this is fine if we keep and eye on it?? Huh? What are the other options other than AZA :-( feeling a little confused. This is the first time not hitting my flare with prednisone and now i refuse to ever use it again as i know i will end up in the loony bin.
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