AntiFimH antagonists for IBD

Thanks for sharing. I do not recall ever hearing about adherent-invasive Escherichia coli in anything I've read related to IBD. Although I've seen various posts from people stating their doctors believe E.Coli plays a role. Great to see more and more treatments being created. I hope there's something to this.

"Through application of its metagenomics platform, Enterome has identified a key bacterial species – adherent-invasive Escherichia coli (AIEC) – which is responsible for triggering inflammation in IBD. AIEC adheres to gut epithelial cells by virtue of FimH adhesion proteins on its cell surface, which bind to the CEACAM6 receptor on gut epithelial cells and allow the bacterial cells to invade the gut wall and proliferate. Research has shown that blocking FimH prevents the adherence and proliferation of AIEC, thereby reducing inflammation and providing new opportunities for the prevention and treatment of IBD.

“The rapid growth of evidence supporting the involvement of the microbiome in serious diseases is providing myriad new opportunities and targets for therapeutic intervention with small molecule drugs,” commented Pierre Belichard, CEO of Enterome. “The unique insights we have gained on the roles of specific constituents of the gut microbiome brought through our metagenomics platform strongly supports the central role of AIEC in inflammatory bowel diseases"

They have known about AIEC at least back to 2001, there is lots of info on it.
Old Mike
www.ncbi.nlm.nih.gov/pubmed/11500426