Cross reactivity of antibodies against microbial proteins to human tissues as basis of Crohns diseas

Very new brief study:

Cross reactivity of antibodies against microbial proteins to human tissues as basis of Crohns diseas
biorxiv.org/content/early/2017/03/13/116574

The above was interesting. A suggestion of autoimmune originating from microbial infection.

I had the author both test my blood sample for MAP antibodies and physically culture MAP. Positive in both cases. Anyway, we shall see where this leads. I remember talking with him on the phone and he kept saying he consistently is able to culture more than one type of bacteria from blood samples in people with Crohn's Disease. Some however argue that some of the other 'types' of bacteria are more likely due to lab contamination - but who knows. Maybe he going down a good path here.

That is sort of one of my theories, we have become auto-vaccinated against our own gut bacteria.
The gut bacteria have somehow escaped the control of the gut immune system and are now presented
to the general immune system.
Old Mike

/www.ncbi.nlm.nih.gov/pubmed/26088200

Primary manifestation of Inflammatory Bowel Disease (IBD) following subcutaneous autovaccination.

Abstract

Onset of inflammatory bowel disease (IBD) is nowadays seen as an interplay or a combination of genetic susceptibility, disturbed intestinal immunity and environmental factors including gut microbiome. However, the initiation of inflammation and progression to IBD pathogenesis in a given individual is poorly understood.In this case report we describe the clinical course of a 17-year old female patient, developing symptoms suggestive of IBD after "autovaccine therapy", in which sterilized samples of the patient's own stool were injected subcutaneously for improvement of her general immunity. The patient presented with a severe onset of disease, which was firstly suspected as ulcerative colitis on outpatient examination and later corrected to IBD with Crohn's- like features in our institution, due to high systemic inflammation, mixed lymphocytic-granulocytic infiltrates in gastric biopsies and further characteristics suggestive of Crohn's disease. A prolonged and complicated course was seen subsequently with intermittent steroid dependency in the long term.Numerous publications postulate that (auto-)immune reactions against resident bacterial stool flora may play a role in IBD. It is possible that in this patient tolerance to endogenous bacteria was disrupted by systemic pro-inflammatory mechanisms induced by autovaccination.