Cannabis saved my wife (CBD and THC)

Hey all,

Long time stalker. Especially last summer when my wife had her most severe flare up to date where she went to the ER twice and was put in observation. I learned a lot about UC from this forum and am grateful for all the info. I wanted to share our success story with cannabis and post a recipe for you all to try.

First a little background on my wife's UC condition:

Diagnosed with UC in 2015. Started taking mesalamine (oral and enema) but eventually became ineffective. She started having semi bloody stools on and off for many months starting spring 2017. I read that VSL#3 could help, but I let her take too much in the beginning, and this caused her to have the worst flare ever. 10+ times a day in the bathroom with bloody diarrhea, high fever, excruciating pain, weight loss, etc. This is when she was hospitalized and the doctor gave her tramadol (opiate painkiller) and uceris. The uceris didn't work, instead it made her joints swell to a point where she could barely stand.

This is the point where I read about cannabis and started giving her joints to smoke. This didn't have much effect as the flare was still raging on, but it seemed to make the pain better. I then made cannabis infused extra virgin olive oil (EVOO) and put them in capsules, thinking that perhaps if she was to ingest the active ingredients it would be better. Besides, I could not find the therapeutic high-CBD flower on the streets, so making cannabis oil means I can add CBD extract into the oil. Also, extra virgin olive oil is an anti-inflammatory in itself. Indeed, the day she took the cannabis oil she started farting, she didn't fart in over a month. This was definitely a good sign. Over the next 6 weeks she took 12 capsules a day and fully recovered from her flare. She stopped taking uceris the first or second week of starting the cannabis oil since she took it for about a month and caused the aforementioned side effects. We didn't change anything with her diet.

At the height of her severe flare, she was taking Asacol HD 800mg, Rowasa enema, Tramadol for painkiller, Uceris. Now she takes 3ml of the cannabis oil and has stopped all prescription drugs except the asacol HD 800mg, which she has cut her dosage down to half (8 pill a day to 4) and is getting fatter, healthier and stronger everyday .

After the 6 week period of heavily taking the cannabis oil, she had some minor relapse where she started to see signs of a flare coming. Whenever this happens she reverts back to a 9ml or 12ml a day regimen with the cannabis oil, combined with imodium. Usually the next day her stools are normal and formed. I have read that imodium doesn't work for many of you but perhaps combined with cannabis oil it may be different. Imodium + cannabis oil synergizes greatly for my wife. There was also a period of time where she took melatonin because she couldn't sleep well. So imodium + cannabis oil + melatonin + asacol + rowasa.

What we have learned is that when the cannabis oil is ingested, and you feel a fuzzy/itchy feeling at the point of inflammation, that means the cannabis oil is working. My understanding is that the location where the inflammation is located (left side for my wife) is where the most CB2 receptors are located. So when the cannabis oil is ingested, it then binds enmasse onto those CB2 receptors at the inflammation site, which causes the fuzzy itchy feeling. After eating the cannabis oil, my wife frequently reported that she felt this fuzzy itchy feeling at the exact sites where she felt extreme pain during the flare.



I hope you guys will try this as it has pretty much saved my wife's life. She is not tolerant of toxic medication and to think that uceris put her in a wheelchair, I cannot fathom what harder meds like prednisone would've done to her. There was also talk from the GI doctor to put her on imuran or some other crazy immunosuppressants. I wanted to share this with you all in hopes that you will try this recipe. Keep in mind it takes some time to completely get off of the flare, my wife took 6 weeks but I was planning for 3 months. That kid Coltyn Turner that cured his Crohn's did 3 months and I was actually modeling the dosage after what his dad was giving him. But after 6 weeks of being high all day my wife didn't want to take any more capsules, so she only took 3ml at night.

Let me know if you guys have any questions. I hope this recipe will calm your inflammation!

Post Edited By Moderator (Michelejc) : 4/3/2018 12:34:41 PM (GMT-6)

I posted the recipe but it got deleted by moderators. I guess we can't post recipes. But it generally is just extra virgin olive oil infused with high THC cannabis and CBD extract added in with the proper 1:1 or 1:2 ratio.

I'm glad you are off your scripts. The treatment list in your signature got some pretty hard drugs in it. That stuff better work fast cuz I imagine being on them long term is gonna cause problems. I know for sure my wife won't be able to handle the side effects.

Post Edited (wifehasIBD) : 4/3/2018 4:11:11 PM (GMT-6)

This is awesome information, thank you everyone for sharing! I am currently on a mission to try some of this out myself. I found that smoking it was helping me at night I was able to sleep through the night with no issues. But I am still currently dealing with the normal issues during the day and was looking into using cbd oil. My question is how much do you think the thc plays a roll in the effectiveness other than for pain. I would like to use cbd oil during the day so I can work without having to deal with the effects of the thc. Also to (deltaforce) how many grams of resistant starch should I start out using. After doing some reading on resistant starches it sounds like it may be very beneficial for someone like myself dealing with Ulcerative Pancolitis, considering resistant starches appear to help the colon specifically. Thanks in advance for help, I am new to this game and this forum has definitely been a big help.

- Diagnosed November 2017 with severe ulcerative pancolitis of the entire large intestine.
- currently on prednisone started at 40mg trying to taper currently at 25mg a day
- humira one injection every 2 weeks
- still in what I guess would be considered a flare 7+ bowels movements a day, no formed stools.

THC and CBD have quite a few differences and I think THC is very worth considering. THC activates the CB1 receptor which is an intestinal transit modulator among other things. CB1 receptors also have increased expression during disease states with anandamide turnover being doubled. Anandamide also activates CB1 receptors so if we could find pure anandamide or an anandamide amidohydrolase inhibitor, that would likely work as well but I've managed to find neither. Just a side note if anyone stumbles upon any information related to this.
CBD has immuno-suppressive(iirc) and anti-inflammatory actions. Both will have an effect and everyone will have preferences but I would consider both of them considering the different actions. I have tried CBD but didn't notice any difference, though I do have other compounds I use for anti-inflammatories and immunomodulators. I plan on going the THC route since my chocolate anandamide idea didn't really help me much and I've noticed transit modulation seems to help me the most.

Yeah, it is quite a lot to calculate. Thc activates both receptors, primarily cb1 while cbd's affects it sounds like are suspected to be primarily on different receptors altogether though they do interact with cb receptors. My study went about that far so I may need a refresher, my current focus has been on ion transport, nitric oxide and prostaglandins which I think I can use to bring myself back to normal. Its been pretty exciting having better days but I still have a lot of digging to do.