Ghrelin and UC

I figured I would share one of the upstream mechanisms I've been studying most recently. I did a forum search and didn't turn up with any relevant results. I was hoping someone may have also studied this and could provide more insight while I go digest my relevant information. Really hoping for some more science to be added although I of course welcome any perspectives.

Ghrelin likely has a large role in Ulcerative Colitis. The therapeutic potential has me scientifically excited. As many of you know, most hormones have many jobs throughout the body and although Ghrelin is associated with hunger, that's far from it's only job. Below are a few studies with a few fun quotes. I likely should have kept tabs on the other studies I've picked through but these are still worth consideration.

https://www.journalacs.org/article/S1072-7515(04)00420-X/pdf

"Ghrelin abolishes TNF-a induced anti-proliferative and pro-apoptotic effects and promotes intestinal epithelial restitutive behavior. Therapeutic utility of ghrelin in mucosal protection and regeneration in IBD warrants further investigation."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278045/

Even the title is interesting. "Exogenous ghrelin modulates release of pro- and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways"

Very noteworthy information I picked from a few studies I don't have on hand, Ghrelin's response to sodium intake. It can be increased or decreased and there was a study showing it affected race and gender differently. I believe there was a term, sodium hunger or something like that which I found interesting.

Also noteworthy is the stimulation of Growth Hormone by Ghrelin.

Also noteworthy is the effect of Growth Hormone on intestinal permeability, intestinal repair and UC.

It's both Leptin and Ghrelin playing a very complicated game of tug of war back and forth. Studying the 2 is pretty amazing in understanding colitis and the many variables that can happen with treatment. I wish there were more tests showing leptin and ghrelin levels and the correlation to treatment responses. I believe Leptin and Ghrelin management may be upstream enough to be an extremely effective treatment due to their effects on the many symptoms of UC.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959465/

Leptin and Ghrelin's role in different types of colitis. Good overview with 94 studies to pull from. It's going to take me a while to dig through this one. I like how they differentiate Dextran Sodium Sulfate studies from trinitrobenzene sodium sulfate studies as one is a better model for immune system involvement.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304249/

Not completely related but remarkable that Ghrelin offset TNF-A increases, stopped the increase in intestinal permeability and staved off nearly all the intestinal damage.