Entyvio question

I don't think there's any way to know, but I do think the fact that you've seen some improvements is a positive sign. Can you attribute the improvement to the entyvio and not the prednisone for sure? I guess at this point, patience is extremely important. Stay positive and wait and see. I've heard of people taking a long time to achieve remission, no reason it won't be the same for you.

It sounds like you've made up your mind and you're going to do more frequent dosing and start imuran? I think that's a perfectly acceptable solution. Staying on pred until you figure out where things are headed is unfortunately a consequence of trying drugs, but with UC, there's no other alternative. Hopefully things are managed in the next couple months and you're off pred for a very long period.

You should try to set a goal for yourself with prednisone, decide when you can tolerate the damage until, and at that point, it's another solution or...? I knew I didn't want to be fat anymore, or zitty, so that was enough for me to say never again.

Has your GI brought up cyclosporine for rescue? Maybe that would get you to 100% so the other meds would have a better chance. I hate how doctors are so quick to say "you're in remission" though, mine always wanted to believe "she did it", but it never happened, even when we thought I was close, it was short-lived, or not even remission, it was all masked by steroids.

When I first started Entyvio I responded fairly quickly ... noticed improvement after the initial loading doses and by the time of the first 8 week infusion I was completely symptom free. I'm still awaiting insurance approval to go to every 4 weeks. Hoping I can have a 4 week infusion on 8/3. I just have simmering symptoms, but the sigmoid on the scope I had last month looked pretty bad. I'm on pred to keep this from getting any worse. I've lost work and have been hospitalized twice with this disease so I don't like to mess with even simmering symptoms.

Hope the increased dosage works for you. I would give it at least a couple months to see improvement, but I like to think even minor improvements may happen shortly after the dosage increase since there is already some Entyvio in your system and it's getting a boost.