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Another C-Diff test done-please help me read results

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Ulcerative Colitis
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Posted 7/18/2018 1:17 PM (GMT 0)
IMMUNOSEROLOGY CDIFPCR means amplified DNA PROBE under Abnormal it says positive under reference its says Negative Equivocal

Interpretive comment it reads: C. Difficile tonigenic gene detected. Toxin assay to follow.

Clostridium Difficile Toxin column it sayd

Analytc Cdif Result negative (under abnormal, there is nothing there) reference is says Negative


My symptoms are every night and during the day green explosive diarreah, pain and bloating. night sweats or running hot all night.

Do I do I not have C-diff, it is so confusing. My last test a month ago said positive then negative.
Posted 7/18/2018 2:31 PM (GMT 0)
Yes. You have c.diff

A gene related to c.diff was detected (positive), and the comparison (which should be negative) was negative. This plus you symptoms means you need FMT as soon as possible.

There are several genes that can be used, and several ways (essentially chemistry experiments) to detect the genes. The methods do differ in accuracy under different conditions, such as how much of the gene was there and the quality of the stool sample. But the methods mostly agree within a few percent of cases.

/www.ncbi.nlm.nih.gov/pmc/articles/PMC3318532/
Posted 7/18/2018 2:59 PM (GMT 0)
I’m going on a new sort of, antibiotics called Fidaxomicin , thank goodness!! I’m oraying this helps me!!
Posted 7/18/2018 3:02 PM (GMT 0)
If your toxins are negative then you DO NOT have C diff. You can always test positive for the gene either by PCR or GDH because once you have had C diff you can carry the gene forever. If you keep treating based on PCR or GDH you will be over treating and throw your gut flora off even more. For awhile the PCR was the gold standard but within the last 5 years UC Davis did a study that said C Diff was overtreated. I almost got over treated as I had +PCR but negative toxins. An infectious disease doc at University of Pennsylvania stopped my local GI from ordering Vancomycin and I was fine meaning no active infection. I then switched to a U of Penn GI as well. So if it says toxin assays are negative than you do not have an active infection although you may carry the DNA of C diff. I hope I read your report right.
Posted 7/18/2018 3:09 PM (GMT 0)
I don’t understand the bathroom problem all day long and it keeping me up at night and the foul smell that’s like death. It’s Superbad. I’m getting blood drawn to see if I have a bike salts diarrhea then .
Posted 7/18/2018 3:26 PM (GMT 0)

countess18 said...
If your toxins are negative then you DO NOT have C diff. You can always test positive for the gene either by PCR or GDH because once you have had C diff you can carry the gene forever. If you keep treating based on PCR or GDH you will be over treating and throw your gut flora off even more. For awhile the PCR was the gold standard but within the last 5 years UC Davis did a study that said C Diff was overtreated. I almost got over treated as I had +PCR but negative toxins. An infectious disease doc at University of Pennsylvania stopped my local GI from ordering Vancomycin and I was fine meaning no active infection. I then switched to a U of Penn GI as well. So if it says toxin assays are negative than you do not have an active infection although you may carry the DNA of C diff. I hope I read your report right.

I see. I may have read things wrong, and will try to find out more.
Posted 7/18/2018 3:31 PM (GMT 0)
What did your doctor say? The green D, pain, and foul smell sound like c diff. The dificid should help. Did you already try vancomycin or did they just start you on dificid?
Posted 7/18/2018 3:44 PM (GMT 0)
Dificid knocked out my C diff in 10 days after failing Flagyl and Vancomycin. If you are going to possibly be over treating then I would use Dificid over Vanco or Flagyl. This antibiotics (which you have now) is supposed to work specifically on the C diff bug and not wipe out all of your flora. It may mask the symptoms of UC for awhile too. If they think you have C diff then push for the FMT to see if that helps the UC. I do know that a positive PCR does not mean you have an active C diff infection though. If you go on the support site Cdiffdiscuss.org- those people know a lot about C diff. The problem with the PCR is - you may continue to test positive for it in the future so you fall into a trap of continuously treating with antibiotics -thus further depleting the gut flora.
Posted 7/18/2018 3:50 PM (GMT 0)
What I read agrees with Countess, a positive PCR could mean non-active c.diff



/www.ncbi.nlm.nih.gov/pmc/articles/PMC4324208/ said...
If the PCR is positive, we can determine with certainty that the patient has toxigenic C difficile, and the final interpretation is positive. It is important to recall that the PCR still does not distinguish between active disease and asymptomatic carriage. This point of distinction remains a challenge in the diagnosis of C difficile, and it serves as an important reminder that testing must be interpreted in the clinical context.

Posted 7/18/2018 6:31 PM (GMT 0)
I never tried Vanco and tried Flagyl for other things (flare) but it seemed to help for a couple days and then stop, never really helped my flare much.

I haven't started it yet, as crazy as it sounds, I've been reading about IBS-D and taking Caltrate 600 D3 for it. Trust me I don't want to be over taking antibiotics either.

I have an appointment with my U0fM doc and see what he says and go from there.

I'm looking into Bile Acid Diarreah too as a cause of this explosive dumping I'm having.

Thanks,
Linda
Posted 7/19/2018 2:03 PM (GMT 0)
Hi Linda,

It looks like you are exploring your options carefully and doing a great job I might add. All the candidate treatments you are considering may be helpful including the Bile Acid Resins. But while your symptoms may or may not be C-Diff, it definitely sounds to me like you are in some sort of bacterial dysbiosis. If it were me and I could talk my doctor into doing FMT's I would go for it, because you may be able to resolve many of your issues in one fell swoop. Just my 2 cents.
Posted 7/21/2018 9:08 PM (GMT 0)
Second test said no c diff, but my doctor put me on cipro and flagyl. I did another stool test to check for more bacteria infection. I have a flex scope on Wednesday. They are tak8ng more biopsy to check for virus’s and to check my ulcers and inflammation
Posted 7/21/2018 11:18 PM (GMT 0)
So why are you still on the antibiotics if no c diff? Is that a treatment for Crohn's since you have crohn's-colitis?
Posted 7/22/2018 1:01 AM (GMT 0)
I don't understand, no infection & the dr rx's two antibiotics. Cipro is known for causing c-diff in some people. Sure would not be a risk I would be willing to take.
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