Single or split dose prednisone?

So after being off of prednisone for only 2 months I’m back on. Humira has been upped to every week. I was supposed to have a colonoscopy last Friday but had a fever when I went to the hospital and was denied. I was covid negative and only had a fever for around 90 minutes. By the time I got back home I was back to normal. I’m on a short course of pred. Starting off at 40. I’ve always have broken it into two doses but think maybe one dose is better(I think this is what the dr wants) . Yesterday I took 40 but last night I was up again as my symptoms came back(less blood and not as painful but still woke 4 times to use bathroom). Just looking what other people do?
Thank you

Just some perspective from an oldie: in early 1990s I was put on 40 mg Pred daily for a severe UC flare that nearly collapsed the lumen of my colon on left side (waste was actually bouncing, barely able to pass thru!). My gastroenterologist broke my Pred dosage into 10 mg tablets, 1 tab 4 times daily. I personally think it's risky to bombard the human body with 40 mg oral Pred taken all in a single dose. My colon responded quickly to the divided dose and I was able to start tapering by 10 mg after 8 days. However, while I continued to taper & flare abated steadily, I still developed "moonface" in my 2nd month on Pred. This is no drug to fool around with because it can affect any other organ or body function negatively. Therefore, I would not trust a doc who advises taking 40 mg dose in a single or even double dose continuously. Pred is not an antibiotic, it affects everything, every organ, muscles, etc.! / Old Hat (40 yrs with left-sided UC; presently in remission taking brandname Colazal)

Post Edited (Old Hat) : 9/11/2020 9:36:29 AM (GMT-6)