What,too much oral butyrate makes DSS colitis worse

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Old Mike

Veteran Member

Joined : Jan 2007

Posts : 4171

Posted 4/22/2022 11:14 PM (GMT 0)

How did I miss this back in 2012.
Oldmike
https://www.ncbi.nlm.nih.gov/pmc/articles/pmc3532546/

VanJordan

Veteran Member

Joined : Dec 2019

Posts : 566

Posted 4/23/2022 12:01 AM (GMT 0)

DSS is a poor model for studying colitis. I wouldn't put too much stock in this.

DSS-induced colitis is essentially a burn. Now imagine butyrate, which dissociates into a weak acid, passing over that burn. Of course it would make it worse.

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