Jyseleca (filgotinib)

Hello friends of healing well,

Thinking of trying Jyseleca for UC flare.
Has anyone tried this? If so, did you have improvement? Good or bad, I'd be really interested to hear.

At the moment I'm on Asacolon 8 x 800mg. (4 in the morning and 4 in the evening). 4g enema Salofalk. Very difficult to retain. I can't eat much as I'II just live in the bathroom. So it's mostly roast chicken and grilled salmon.
This all got bad when I got cystitis awhile back. I then had to do two courses of antibiotics to clear this up.

Hi, just wanted to point out that the UK is still part of Europe 😁

Apart from that, jyseleca is similar to rinvoq (upadacitinib) in that they are both JAK-1 inhibitors.

Xeljanz, the first JAK-inhibitor to be licensed for UC, inhibits both JAK-1 and JAK-3.
In being more targeted, it is probable that jyseleca and rinvoq are both safer and more effective than xeljanz. More data on this will become available in time.

That being said, all 3 drugs are particularly effective in patients who have failed to respond to biologics and other treatments. Since most people who take these drugs do so as a "last resort" it's hard to know whether these drugs are more effective for all UC patients or whether it's to do with blocking a particular immune pathway that's important in a subtype of UC.

Either way, yes many of us have had great success on these drugs, often when we had run out of other medical options. And they work FAST as well (can usually notice changes in the first week)

Good luck.

I'm on Xeljanz and so is my boyfriend. I tried it after the other meds didn't work or failed. My boyfriend tried it as his first medication after mesalamine (and a course of steroids). Neither of us have side effects. I've been in remission over a year and he has been for over 2.5 years. I know it's not the exact same med but hopefully that helps a little. Hope it works for you! One pill a day is awesome. So much better than infusions, too.

Two weeks to wait on bloodwork is a lot--sorry the steroids are not working. How long have you been on them and at what dosage? And yes, request a stool sample test for c diff.

Thanks Sara. Gives me hope🤞
I'm not on steroids at the moment. Just being careful with food.
I've done two courses of IV steroids in the passed and never got good. Always blood for months after. Just being careful with diet and doing supplements helped. Never full remission though.


Well they were able to speed the blood reports up a little. So I'II know next Mon/Tues. X-ray done too. So if Jyseleca doesn't work out. I'II try Vedolizumab.
My IBD nurse said I should know in a few days, if Jyseleca was going to work in my system. Amazing if it did and only a few days to know. Not like weeks with other meds.

Good luck! I'm not sure what your nurse meant about knowing in days. Some people see results in days but most it takes a little longer than that (I'm only speaking of Xeljanz but assuming it's the same). It took me 9 weeks to be completely symptom-free. Just don't want you to give up if you don't feel better in a few days.

I’m sure the blood clot risk is minimal but I would seriously keep up with your Covid vaccine schedule. As an IBD patient we are already at higher risk for blood clots and Covid causes blood clots so it’s something that I vigilant about trying to prevent.

Hi Sara14, Yes 5 weeks on this now. Only seen a slight improvement. It's similar to biologics, so can take up to 12 weeks to kick in. I've mild headaches from it. I take CBD oil for this. Started Cortiment at the same time.

Met up with my doctor the other day.
He did an ultra sound on the colon and there's bad inflammation in the rectum and sigmoid 5cm deep was some of the ulcers.
Now on steroids, Cortiment, Salofalk 3g granules and Fortisip compact protein drinks x 2. My weight is very low. Down to 44k (my usual would have been 51k) and I'm 156cm.
Would love to be able to hang onto the Salofalk 4g enema. Anyone got any tips for this? I've tried doing it on my left side and lying on the bed for a bit. I only last a few mins.

Flowermay45 - did you start it yet? How are you doing? Hope it's working out for you. I'm trying not to look too much into side effects. I really need this to work. I'm at the end of my rope with this illness. Christmas is coming and biggest and best present I could get is remission.

Also I am totally fed up with the flare up. Hard to keep positive. Sending you a virtual hug. You’re not alone 😊 x

My last msg was meant for Flowermay45
Mixed up the names.

I’m just devastated to be back in hospital. I hope stelara works🤞

Sorry that you are in the hospital. Hope you feel better soon!

Tips for retaining enemas -- warm the bottle in hot water for a minute or so and slowly squeeze the air out of the bottle before inserting.

How are you now? Have you tried Xeljanz?