BG: My dad grew up in Monessen. Anyhow.
D-BHB exogenous ketone supplement you don't need to be on a keto diet,but many do well on keto or carnivore.
I was not on keto.
To understand everything see my thread here,you must have seen it,has 10K views.
https://www.healingwell.com/community/default.aspx?f=38&m=4320011Nutshell: Also need to be adequate on,Zn,Cu, Se and Mn
Diversion colitis=colonocyte starvation-UC=Colonocyte Starvation??????
UC=Blocked fuel import and usage. Diversion Colitis-No stool,no fuel.
IMO-Based on studies.
Genetics a given.
Colonocytes get most of their fuel from short chain fatty acids acetate, propionate and butyrate,butyrate being preferred 70%. the other 30% glucose and glutamine. The fatty acids come from fermentation of fermentable/soluble fiber in the colon.
The butyrate is transported into colonocytes to supply energy via beta oxidation,beta hydroxy butyrate a ketone is formed. Hydrogen Sulfide from fermentation of ingested sulfur amino acids/bile acids via SRB's may cause a beta oxidation inhibition if detox pathways not functional. Peroxides block beta oxidation at thiolase which is downstream of the dehydrogenase which is first inhibited by H2S. Peroxides also block transport into the colonocytes via MCT1,in the rectum butyrate can enter via diffusion. Detox mechanisms weakest in rectum,that combined with high bacteria load is why UC starts in the rectum. H2S can also thin mucus.
Now excess unused butyrate,which penetrates to the crypts, inhibits the stem cells, therefore inhibited barrier repair.
Now bacteria/also dysbiotic can penetrate and activate the immune response,causing destruction,more peroxides,many cytokines such as TNF,infiltration of immune cells/oxidative bursts.
The colonocytes now only have glucose and glutamine for fuel,glutamine further converts to ammonia which also inhibits beta oxidation. Then you can run out of glutamine,which leads to less gluthione,and more destruction from H2O2.
Now a metabolic mess,with disrupted bacteria,probably due to excess oxygen in colon,bleeding,disrupted barrier,immune attack.
Missed many steps I'am sure, but IMO in a nutshell this is what is going on.
All the studies are in this thread,start at page 1,back in 1980. Took me 43 years to connect enough dots. ...............
If I'am wrong,well been wrong many times in the past. But as far as I can tell the above is based on as
many facts as I could find. Yes Facts.
oldmike