Could Proton Pump Inhibitors Cause Cancer?

Hi There friends,

Say, I found that by pure coincidence on the net yesterday and it dates to october 2010. as anybody red this?


Vol. 170 No. 19, October 25, 2010
Could Proton Pump Inhibitors Cause Cancer?

Paul J. Rosch, MD

In addition to increased risk of osteoporotic fractures, Clostridium difficile, and other infections, proton pump inhibitors (PPIs) may have also contributed to the sharp rise in gastroesophageal malignant diseases seen over the past 2 decades. This is especially
true for esophageal adenocarcinoma, which was previously uncommon, and mirrors the increased use of these drugs. It has been suggested that with PPIs, pancreatic enzymes that would have previously been inactivated by hydrochloric acid are able to irritate
and cause dysplasia in esophageal tissue in patients with reflux disease. There is also evidence that gastroesophageal reflux disease (GERD) may not develop from direct superficial injury but rather from stimulation of esophageal cytokines that attract inflammatory
cells to submucosal tissues. Indeed, patients with GERD usually show no evidence of mucosal damage on endoscopy. The earliest changes appear to be dilated intercellular spaces in the esophageal epithelium. In one . . . [Full Text of this Article]

AUTHOR INFORMATION
Author Affiliations: Departments of Medicine and Psychiatry, New York Medical College, Valhalla, and The American Institute of Stress, Yonkers, New York.



Now, That's too bad I could not find the rest, but, here we... well, I mean, I go again, freaking out on this question of: are PPI safe or not safe long-term, for christ sake?!
I mean, I am sooo tired from time to time to find some reports that says that its safe long term and after a while others that says that they are not! I think I understand the
explanation of the report here, but, dawm, seems like my anxiety disorder will never cease! :-( I have been on Pariet for almost 8 years now and even if my latest scope
(from 4 months ago) apparently showed a normal stomach and eosophagous, when I read this:


...Indeed, patients with GERD usually show no evidence of mucosal damage on endoscopy. The earliest changes appear to be dilated intercellular spaces in the esophageal epithelium...


I am not so sure anymore, I mean, even a Gastroenterologist can miss something, right?

I am so sick of all this, you have no idea! or, maybe some of you do! so, I don't know for you guys, but I am seeking some encouragements after reading
this because frankly, it puts me down the drain...


Thanks for reading!


Frenchster

I took PPIs for ten years until they stopped working for me. IMHO if you need PPIs for that long and are not getting relief then you need surgery.
Nexium does state that long term use of their product can cause benign stomach polyps which will fade away when stopped.

 Can't say for sure, but it's really odd that after being on nexium for about 7 years, I had a scope and was told I had Barretts Syndrome. Now, being on nexium, how did that happen? I didn't have it when they put me on nexium. Now after aprox. 12 years of being on nexium I have gastroparesis. It's horrible! I'm wondering if the nexium has caused this. I have been reading that nexium should not be taken long term. I would call 12 years very long term. What is wrong with Doctors today? I have come to the conclusion that we are not people to them, but merely numbers, and they handle more numbers than they can keep up with. I have even read that nexium can cause gastroparesis. Proton pump inhibiters are evil. I am trying to go off nexium, but the pain and suffering is too much to bear. Next, I suppose nexium will kill me.

i was on prevacid (30mg 2x a day) for about 8 years and got alot of benign polyps from it. the dr would take out some during endoscopies, but said they were harmless. i switched to protonix (a ppi) this summer as prevacid became too expensive, since it's over the counter.

so far, nothing dangerous from the ppi's all these years and hopefully nothing will happen, as im 20 so i'll be taking them for a long time. my dr. said i didn't need surgery, that it doesn't really work for people with GERD all the time. i didn't push it, because for now, im fine just taking the meds 2x a day and it works with some zofran when needed