LPR - success with PPIs? How long?

I have read in several places that treatment with PPIs for LPR should be at least 6 months of a twice a day dosing.

So far I am just over 2 months in at 2x a day Omeprazole. Though my main symptom (globus/tight throat) was improved significantly within days from 1x/day PPI, it has led to other LPR symptoms like bitter taste, cough, and continued though lessened throat tightness. I have not noticed any change being on 2x/day PPIs.

Has anyone here noticed significant improvement on PPIs for LPR, to the point of no symptoms? I am not encouraged by what I've experienced after 2 months of this dosing.

Thanks.

Hi drtinsac,

To offer you some words of encouragement...hang in there. I too have LPR/GERD. I developed it last April suddenly. I went w/o meds for 5 months before I relented and began taking 30mg of Prevacid 24HR 1x/day. It took 2 months before I noticed a significant change and by 4 months I became SYMPTOM-FREE. I now have some slight throat coolness/burn which I would rate as 1/10 maybe one day a month though I have gone 50 days or so without any of that. I was just like you in feeling like the meds wouldn't work. One thing you have to keep in mind is that you cannot just take the meds and still eat whatever you want. PPI's + avoiding trigger foods works way more often that PPI's alone. It takes a while for your throat tissue to heal from the acid burn it has incurred over months or years. Be patient, avoid trigger foods, and make sure you are taking your first dose of PPI's AT LEAST 30 minutes BEFORE eating in the morning.


Good luck,
Liz

I have been taking 30mg Lanzoprasole 2X a day for 4 days.  Still experience a very sore throat when I eat anything.  I have been on the Kaufman diet for two weeks.  I was hoping for a faster healing of my throat, but no change yet.