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Newest interesting research on GERD

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Posted 9/25/2012 2:03 PM (GMT 0)
I had a flare-up today after a long period of calm, and as a habit, I searched and read GERD-related stuff to calm myself down.

Here are some interesting stories I found, on Medscape.

#1 Short-term electrical stimulation of the lower esophageal sphincter increases sphincter pressure in patients with gastroesophageal reflux disease.

reference.medscape.com/medline/abstract/22292889

You may have already heard of the EndoStim device. But this study just independently confirmed the feasibility of the treatment using electrical stimulation.




#2 Positive effect of abdominal breathing exercise on gastroesophageal reflux disease: a randomized, controlled study.

reference.medscape.com/medline/abstract/22146488

Somebody said...
We show that actively training the diaphragm by breathing exercise can improve GERD as assessed by pH-metry, QoL scores and PPI usage. This non-pharmacological lifestyle intervention could help to reduce the disease burden of GERD




#3 Rikkuncrapo improves symptoms in PPI-refractory GERD patients: a prospective, randomized, multicenter trial in Japan.

reference.medscape.com/medline/abstract/22081052

Rikkuncrapo is a Japanese traditional herbal medicine. There are at least a dozen of studies conducted by Japanese to show the efficacy of it in treating functional dyspepsia and now GERD.




#4 Oral nitrate reductase activity and erosive gastro-esophageal reflux disease: a nitrate hypothesis for GERD pathogenesis.

reference.medscape.com/medline/abstract/21881975

A new alternative theory on the cause of GERD. It's very different from the usual LES weakness theory.

Post Edited (WJF) : 9/25/2012 8:06:28 AM (GMT-6)

Posted 9/25/2012 2:10 PM (GMT 0)
Thank you for the information. I think you have to sign up to see it, but it is free. I will read the links you provided.
Posted 10/2/2012 2:20 AM (GMT 0)
Interesting study of using Rikkunsh ito for GERD.

I've been trying to search online .. but am unable to find information on where and how to obtain Rikkunsh ito. Any pointers on how to obtain this herb in the US will be greatly appreciated.

Post Edited (PPI-LESS) : 10/1/2012 8:24:10 PM (GMT-6)

Posted 10/2/2012 10:00 AM (GMT 0)
The oral nitrate link is also interesting - but I'm wondering how does that translate into action? Other than avoiding medications that contain it, which may not be possible if you need GTN, should we be avoiding all processed meat (a lot of us already are) and foods like spinach which contain a lot of nitrate??

MMM
Posted 10/2/2012 10:32 AM (GMT 0)
Anyone remember the zinc chloride study?
http://www.nature.com/ajg/journal/vaop/ncurrent/full/ajg2010327a.html

Looks like it may now be possible to obtain this as a supplement - I've found one product so far in the UK containing 3 forms of zinc, zinc chloride being one of them. It's been 2 years since the study - I'd have expected more products out by now!

MMM
Posted 10/7/2012 3:05 PM (GMT 0)

PPI-LESS said...
Interesting study of using Rikkunsh ito for GERD.

I've been trying to search online .. but am unable to find information on where and how to obtain Rikkunsh ito. Any pointers on how to obtain this herb in the US will be greatly appreciated.

In the city I live, I am able to get my hands on the Chinese traditional medicine from which "Rikkunsh ito" is derived. I think the Japanese went one step ahead and did several studies and trials on these traditional herbs. I think they have a different, improved formulation after identifying the more potent ingredients in the old formulation.

Paper said...
Traditional Japanese herbal, or Kampo medicine was developed and modified from Chinese herbal medicine. After the Japanese government approved Kampo for clinical use, much attention has been paid to establishing scientific evidence for the effectiveness of these medicines. Recent progress has been made in elucidating the mechanisms of action of some types of Kampo medicine, including "rikkunsh ito" (RKT), daikenchuto, and yokukansan.

I think the only way to get this "Rikkunshi ito" is to buy from Japan. smilewinkgrin
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