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Rebound effect?

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Posted 5/2/2013 5:59 PM (GMT 0)
Hello everyone, I was diagnosed with GERD four mounts ago, I have been on 40mg Pantoprazole for 11 weeks straight, it was helpful, I've had an upper endoscope test (two weeks ago) with pretty good results (minimum damage of esophagus), I am on Kaufman diet (works for me), I've lost almost 10 kg (!) during this time and finally started to feel almost good (still have lump sensation in the throat), anyway, I've decided to stop using Pantoprazole (GI Specialist said (after endoscope test) that I can stop PPI anytime and enjoy my life). I've read a lot about rebound effect when people stop using PPI, so I've decided switch from Pantoprazole to Ranitidine (I started my treatment with it). The first three days I felt very good, but today I started to have lump sensation on the chest - exactly the same like I felt before my treatment. The problem is - I don't have heartburn (and didn't have it regularly at all). My question is - is this lump sensation in the chest is rebound? I still hope that I wouldn't have rebound effect but I really can't ignore this strange feeling.
Thank you all and sorry about my mistakes. :)
Posted 5/2/2013 8:03 PM (GMT 0)
In my experience, what I experienced as rebound was similar to what I'd experienced before the drug. Plus I had an episode or 2 of heartburn which I never had before the drug. I can't speak for others, but I wouldn't be surprised if that is how it goes. People experience symptoms of reflux differently, and those specific symptoms will probably reoccur or perhaps be more pronounced during rebound-- since that is how your body responds to reflux.
Posted 5/2/2013 8:22 PM (GMT 0)
drtinsac, thanks for your reply. From your experience - for how long your rebound lasted? and how did you reduce it? antacids? DGL?
Posted 5/3/2013 12:15 PM (GMT 0)
Tania,

Rebound can last up to several weeks, depends on how long you were on ppi's. You can try to control with tums, dgl, aloe, manuka honey, zantac, and other natural supplements to help sooth. As for the lump, chewing gum does offer some relief.

Posted 5/3/2013 5:56 PM (GMT 0)
I find it ironic that one of the side effects of ppi's is heartburn...ahh, isn't that what there meant to relieve? Prior to my surgery I was on PPI's that kinda helped, when I switched to Zantac like you it worked alright, but I found relief taking it twice a day. In my experience Zantac's twice a day worked better than any PPi that I tried

Also, doesn't Zantac have a shorter half life than PPI's? Maybe since you switched to a H2 antagonist you have less acid suppression throughout the day and night? Maybe start taking the zantacs twice a day for a couple weeks untill the rebound caused by the PPI goes down.

Also, I had a lot of side effects with Zantacs. Not sure if that's the case with you, but I found pepcid ac to be helpful also with less side effects.
Posted 5/3/2013 9:13 PM (GMT 0)

DOGGBONES said...
Tania,
Rebound can last up to several weeks, depends on how long you were on ppi's. You can try to control with tums, dgl, aloe, manuka honey, zantac, and other natural supplements to help sooth. As for the lump, chewing gum does offer some relief.


DOGGBONES, thank you.
Posted 5/3/2013 9:25 PM (GMT 0)
TheSixness, forgot to say - I have some kind of UTI these days also, so I am on Ciprofloxacin (three days) - and hope my symptoms from it. Thank god, I finished taking it today and I hope to feel better in a few days. And yes, I take Ranitidine (generic from Zantac) twice a day.
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