Posted 6/20/2013 5:01 AM (GMT 0)
I actually had the opposite problem. I had swallowing problems from LPR before I started taking PPIs and then started having heartburn after I had been on them for a while. Now I constantly have heartburn, and swallowing problems.
If you are trying to find a way to explain rebound, temperature is the wrong thing to think about. Your stomach is constantly secreting gastric acid in small amounts. More is secreted when food enters the stomach or even when one starts to think about food, but it is actually constantly being secreted.
Proton pump inhibitors restrict the amount of gastric acid that is secreted both around the clock and around meal times, but specifically right before meals. This is why doctors instruct patients with heartburn to take PPIs 30 to 60 minutes prior to meals. I say both because there are also some PPIs that are designated for an entire 24 hour period.
While you are taking PPIs on a regular basis, acid secretion is being suppressed, eventually to the point that your stomach has a new "normal" amount of acid it wants to produce, since that is what it has been doing for so long. It's like you're pushing a large box across the floor, and your friend is standing on the other side pushing against you to slow you down. Once there is more resistance from the PPI or your friend, you need to work even harder to accomplish the same goal. The stomach has to work harder to create it's "normal" amount of acid on PPIs and you have to work harder to push the box against your friend pushing back.
When your friend suddenly decides, to step away and stop pushing against you, you can push the box a lot farther while you are still doing the same amount of work. Going off PPIs is the same way. Once you stop taking them, your stomach continues to produce what it considers to be the "normal" amount of acid it should make, but without the resistance, much more is created. The difference is that as a person pushing a box, you can adjust to changes quickly due to free will. Your stomach will continue to have the same "normal" amount of acid secretion long after you decide to stop taking PPIs. This amount of time has not been narrowed down, and varies a lot between different people, and this is the phase you see people commenting about all the time on this forum.
H2 blockers work in a similar way to limit gastric acid secretion, but not in exactly the same way. For this reason, it may be helpful to consider switching to another medication, but know that each medication within these two categories are very similar to each other.