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PPI stopped working after 4 weeks. Help!

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GERD & Acid Reflux
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Posted 2/8/2015 12:19 PM (GMT 0)
Hi there. I have quite severe GERD and the dr. started on 20mg of nexium 4 weeks ago. I felt great until last week when my heartburn suddenly came back again although not as much as before. The dr. changed my dose to 40mg but it doesn't seem to have an effect still mild heartburn everyday. I'm worried because I also have short segment Barrett's.

Can anyone tell me what I should do or if they've experienced anything similar.

Should I go to an even higher dose? What if that doesn't work either?

Do some PPIs work better for some people than others? Is there a chance lansoprazole of one of the others will work better for me?

Any advice or share experience much appreciated!
Posted 2/8/2015 4:53 PM (GMT 0)
have you changed the timing of taking it at all?

I notice big differences in its effectiveness depending on when I take it as well as what I eat afterwards.

It should be taken on an empty stomach, about 30 minutes before a meal I found works best for me. The meal after should have protein and some fat to stimulate acid production
Posted 2/10/2015 7:23 AM (GMT 0)
Thanks for the reply Andy, appreciated. I take mine about 20 mins before a breakfast which does have protein and fat. Funny thing is Nexium worked fine for the first month or so. No heartburn at all. Then suddenly it was back again, albeit in a milder form...
Posted 2/10/2015 2:03 PM (GMT 0)
Hi Tk44

Many people assume they have too much acid when they have heartburn or reflux..But these are also signs of Low stomach acid. If there is not enough acid in your stomach, the stomach cannot break down food quickly. When food stays in your stomach too long (called delayed gastric emptying), the food and the remaining acid left in the stomach will be pushed back up the esophagus causing heartburn, reflux, and in worse cases vomiting
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