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PPIs stop working after a while

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Posted 11/23/2017 3:18 PM (GMT 0)
Hey guys.

Just wanted to check if anybody here knows why different PPIs eventually stop working.

Generally I have success with PPIs, and I am essentially sympom free when they work. The problem is after a couple of months they just stop working for no reason and I have to switch over to another type.

For example: This summer I was taking 30 mg lanzoprazol which worked great for several months. For no apparent reason, in September I start getting symptoms of burning stomach, coughing, and sore throat so I switched over to omeprazol and was doing great on 20mg daily. A week ago omeprazol stopped working so I switched over to lanzoprazol again, and I am currently waiting for it to kick in.

I am just trying to figure out why this is happening because my body respond great to the medicine when it is working. Does anyone have any idea why these different types of PPIs just stop working for no apparent reason?

Best regards,
Jakob
Posted 11/24/2017 8:25 PM (GMT 0)
No idea why this happens. When I first had re-flux problems many years ago I was prescribed Lansoprasole. It stopped being effective after some time. (Not certain how long). Went on Omeprasole which worked wonders and have been on that for many years. However I had a mini stroke at the beginning of October and was prescribed Clopidogrel blood thinning tablets. Had to come off Omeprasole as they negated the Clopidogrel effect. Have had to stay off all PPIs until today as I was due to have an endoscopy. As you will imagine re-flux was a nightmare until I discovered that when I experienced it, chewing 2 or 3 almonds had an almost instant curative effect. Remember though that the almonds do not prevent re-flux they only alleviate it. My endoscopy discovered that I have a hiatus hernia and Oesophagitis Duodenitis. I am now back on Lansoprasole (2 per day) and will be rechecked in 2 months.
Posted 11/26/2017 4:06 AM (GMT 0)
Hi all, I think it's about tolerance. Your body has hit its tolerance to that med so the body demands higher dose. That's why I have problem with these drugs. Any long term drugs could have this problem. Tapering down slowly is a way to handle this issue (that's if you want to). But, of course, consult your qualified health practitioner if you want to change or taper down your dosage. I hope you find relief soon.

Post Edited (exbenzo) : 11/25/2017 9:10:17 PM (GMT-7)

Posted 11/26/2017 7:19 PM (GMT 0)
All - I agreee with exbenzo but I just want to add that you may want to go on the GERD diet. If you have a hiatal hernia then it may be getting bigger. It may be time to see a gastroenterologist, and have further testing. I had heartburn for 30 years before I had surgery.

The almond perspective is interesting.

I started on over-the-counter, added TUMS, then eventually went on Aciphex (PPI) twice a day. Don’t let the heartburn go untreated because it will damage your esophagus.

Post Edited (Yellow1955) : 11/26/2017 12:23:04 PM (GMT-7)

Posted 11/27/2017 3:23 AM (GMT 0)
Yellow1955: I agree. So far, my GERD has gotten better when I try my best applying low FODMAP diet in conjunction with low histamine diet You can search Yasmina Ykelenstam about histamine intolerance. I extract both diets and then make my own combination that works for me. I keep evaluating. I also know that low FODMAP diet is not meant to be long term, and I'm trying my best to not eating excessively, giving time between each meal, chew my food into liquid, not swallowing the next food on spoon too fast (this can be done with my time period chewing the food that is in my mouth), not drinking too much water during meal (give it time 30 minutes), doing small relaxed walk after big meal to fasten digestion, exercise, posture correction (not slouching too much), doing acupressure, vitamin D from sunbathing, diaphragmatic breathing, and also not lying down after meal. Don't forget the raising your head thing when sleeping.

I read that medical-wise, GERD can only by cured by LES surgery. So I hope I can do my best to manage mine. Best wishes to all of you.

Post Edited (exbenzo) : 11/28/2017 1:31:27 AM (GMT-7)

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