acid reflux and ppi sounds stop working

i am 52 years old man, i had acid reflux around 30 th but not so bad, only felt heart burn. last year-2017 around March i got chest pain, then i did endoscopy and found i had grade A GERD, and my doctor give me Nexium 20 mg, after a year i did endoscopy again to check stomach problems and found i had dadida in the esophagus and i took anti fugal medicine but do not know candida gone or not as no related symptoms.
then i tried to get rid of ppi as i concern side effect for long term ppi but failed and i went back to ppi 20 mg a day. unfortunately, about 4 weeks ago, 20 mg ppi sounds stop working, then my doctor give me 40 mg ppi, it works but not as good as beginning i took ppi a year ago. but if i take some antacid like Gaviscon, it helps, so i think the ppi not reduce acid a lot anymore for me.
so only one choice for me is to do fundoplication? any one has similar problems, what did you do to deal with this situation.
thanks in advance for any advice.
auyyg.

I suggest that you follow a strict GERD-friendly diet and keep a food diary to try and pinpoint your trigger foods. Exercise and weight loss (even the smallest amounts) do help. The Nissen should always be a last resort. It is major abdominal surgery and recovery can be long and difficult. You need to give your body a chance to adjust to your new dosage of Nexium, since you at one point stopped taking it completely If Nexium has stopped working for you, there are a lot of new PPIs on the market that you can try. If you decide to discontinue PPIs again, you need to wean off of them slowly. There is also a liquid medication called Sulcrafate that a lot of people have had success with.

Sharon

I agree with SharonZ that surgery should be the last resort.

I was on PPI for years. Actually they started me on an over the counter back 14+ years ago. I was thinking 10 but my wife says at least 14 and that actually makes more sense.

I had reflux sometimes. I think it was my weight and eating habits. I was overweight although I lifted weights and plays a lot of pickup basketball. I would eat late sometimes and ended up sleeping. Young and not thinking really. Just the burning though. No regurgitation and stuff.

The PPIs were changes over the year. My dose increased. I had issues I never related to the PPIs until about a month ago.

I was given a double dose and then started having nighttime regurgitation. My random heartburn and stuff was due to not having symptoms and not thinking when I ate. So when I had a scope they found erosion and biopsied but no Barrett's.

It was mistaken by my GP that the GI doctor said I had Barrett's.

Too make this short I got scared because the double dose was making things worse. I had not linked the PPIs. I was on nothing else. The confusion, joint pain, muscle pain, everything, just go worse. Then the few random regurgitation bouts. Tiredness was getting worse. My GI then told me I needed an H2 with the double dose of PPI. This really got me. Plus my GI said surgery was next.

Then, my 19 year old son started talking. They put him on PPI for heartburn 3 years ago. He was getting tired like me. He was having digestion problems like me. Food just sitting on the stomach.

I started looking and found that more on PPI actually have been shown in studies to get Barrett's than those no on PPI. Read several studies on that. I saw the other studies and read peoples stories. Heck, I was diagnosed with Fibromyalgia due to "fibrofog" and other issues that had no explanation.

Because of my son I took to my GP and asked him to take me off them. He gave me a strong H2 does twice a day to help with rebound. I was lucky. I have had only 2 minor rebound instances since. One was because I missed the evening does. I was skipping the morning one anyway. The other was I got in a hurry drinking some water and swallowed a huge air bubble. But other than that I have controlled it.

My son, he has no heartburn either. Off PPIs and his symptoms are gone. I have no muscle aching now. My strength is already improving. And I feel much better.

Just reading around I have found that PPIs tend to get increased over time. They lose some effect. But they can have bad effects long term. Even the head of 2 big PPI companies said "If used as intended, 6 months at most" PPIs are totally safe".

I really hope you can get better. I really hope you can find a control method. Diet, weight, other things that can get you off the PPIs. They really do not recommend them for elderly people and we all, hopefully, make it to be elderly. I read on here just because of my own symptoms. I did not want surgery. And I realize how important it is to avoid that as well if possible.

I would be careful though. Talk to your doctor. They may be able to get you off the PPI slowly. Rebound acid happens to a lot of people. Healthy people that never had reflux that took them for some studies. They may be able to get you off them with other medications and then roll you down to something that works that you take at certain times. I really hope you can get better.