Billy,
Interesting study I remember reading somewhere awhile ago. It said two doses of PPI greatly reduced acid coming up while sleeping but it also made the non-acid (bile, enzymes) reflux increase while sleeping. Thinking is regular acid reflux will hit your throat and make you wake up, but the non acid may do more damage by sitting in your throat and not causing you to wake up.
I am sure some of our wise members will have input for you.
Kindly,
Kitt