Posted 4/21/2014 2:00 PM (GMT 0)
In the rat model, esophageal adenocarcinoma reproducibly develops following surgically induced duodenal reflux into the esophagus and administration of nitrosamine. In addition, decreasing gastric acid via partial or total gastrectomy increases the prevalence of adenocarcinoma in this model
http://www.ncbi.nlm.nih.gov/pubmed/9841983