According to this new study: https://www.jefferson.edu/about/news-and-events/2020/2/statins-may-lower-mortality-in-high-risk-prostate-cancer-patients.html Art...
Apparently, the Phase III trial testing the effectiveness of Apalutamide in patients with non-metastatic castration-resistant prostate cancer has been successful, and Janssen has submitted the New...
Dear snowcake, The most important thing is that you are providing your dad with incredible support. I'm in a similar situation with my dad, whose cancer spread to bones after years in remission. You...
YONSA is a new formulation of abiraterone: https://www.churchillpharma.com/media/churchill-pharmaceuticals-announces-submission-of-nda-for-novel-oral-formulation-of-prostate-cancer-treatment/ Does...
Hi snowcake, Much more experienced and insightful people will comment shortly, but I just wanted to write and say don't despair. First of all, I don't think it is possible to spread mets simply by...
Tokai has announced that their Phase III trial of Galeterone vs. Xtandi for patients with AR-V7 tumors has been suspended. An Independent data monitoring committee has "determined that the ARMOR3-SV...
Faustmann, Great to hear about the big drop, always good news! My dad did the reverse, he switched from Xtandi (couldn't handle the sever side effects) to Zytiga. The PSA was slowly but steadily...
I agree that approaching PC from the point of view of managing it as a system, seems like the most comprehensive way of making sense of it. My dad's oncologist put it in a way that I found rather...
I think Allen has mentioned a few times this new radio-pharmaceutical that is being developed in Germany, PSAM-linked lutetium-177:...
Faustmann, We have asked our oncologist about PSA and Zytiga. He said that occasional upward movement is not necessarily a sign that Zytiga has failed. What matters is the general pattern of the...
Allen, Does make sense. It's good to hear that at this stage of the disease, random events could occur in our favor....
A bit of a general question on metastatic cancer cells. Is it correct to say that not all metastatic PC cells multiply aggressively? In other words, is it possible for someone with bone mets to...
John, It's so tough to hear about your dad. I'm keeping a close eye on my dad as he is basically castrate-resistant at this point, but I wanted to add my input about Zytiga. What we've been told is...
Teamchris, As Allen suggested above, it seems like your husband should most definitely consider Zytiga and/or Xtandi. Both were initially approved for people progressing on chemo. In fact, I think...
Approval will most likely follow within 60 days. This is exciting news for people who have these specific mutations and have gone through chemotherapy and at least one of the second-line ADT (Zytiga...
Such great news, congrats to both of you! (And such an amazing persistence with all the different therapies, you guys are amazing!) Will definitely share this news with my father, especially the part...
Hi Teamchris, As others have written, don't despair. Most likely, your husband will be placed on Xtandi or Zytiga. It might also be a good idea if his oncologist can use both Zytiga and Xtandi at the...
That is true. Xtandi's manufacturer has a Patient Access Program, where patients can apply for financial aid. Carefully worded applications get approved in such circumstances, similar to what's...
Hi mydadismyhero, We were told that the effectiveness of Xtandi should be evaluated after the 3-month mark. PSA response may go down, even after not moving much at the 2-month mark. If you dad can...
My dad was on Xtandi, while hormone sensitive. He was on a Lupron+Casodex regimen, and the Casodex was switched to Xtandi. F18 PET/CT scan showed bone mets, so the oncologist decided it was best to...
http://www.esmo.org/Conferences/European-Cancer-Congress-2015/News/Anti-tumour-Activity-Demonstrated-with-Orteronel-in-Metastatic-Castration-Resistant-Prostate-Cancer Even though Orteronel failed...
Treatment resulted in prolonged radiographic progression-free survival, but it did not extend overall survival....
Mel, My understanding is that, as long as ADT manages to bring your PSA down to undetectable, and you have no identifiable mets on scans, you're in a really good place. Having your PSA be at such low...
Dad's PSA came back at 0.10 this month. Good news, continuing a slow decline over last 4 months while on Xtandi (+ Lupron, etc.). PSA has crept down from 0.7 to 0.1, so we're very happy. Xtandi...
Luca, My deepest condolences. Reading your posts over the last few years, it's been inspiring to see how you and your family have been such an amazing support team for your dad. Best, Arthur...
Cyclone, Very glad to hear that Zytiga is working for you already! Just wanted to add that our oncologist emphasized that with Zytiga and Xtandi, it is prudent to take them for at least 3 months, to...
Todd, Here's our best wishes that your dad's condition is operable and treatable! All the very best, Arthur...
Oh, and to add, the Xtandi patient info sheet itself mentions that if side effects become unbearable, one could stop the drug for a few days and retry, or cut the dose in half (2 pills, rather than...
Hi Deanna, My dad is three months in on Xtandi, and while he doesn't have chest pain, his blood pressure is going crazy: unpredictable rises that happen a various times every day. So, we've got to be...
My grandfather was treated for his PC between ages 83 and his death at 93. If I remember correctly, he had three-month Lupron shots at the beginning, and I believe towards the end, it was just...
Congrats! Do you know when they'll publish the results of the trial? Arthur...
Keep fighting! Here's to hoping that .2 will go right back to <.1. Arthur...
Hello Infohound Others who are much more knowledgeable will respond, I'm sure, but right off the bat, what about trying Xtandi, or re-trying Zytiga. From what you wrote, I'm taking that he responded...
That's really interesting and good news! So, potentially for some people, they could respond to Xtandi/Zytiga, then develop resistance, switch to Taxotere, develop resistance, then try Xtandi/Zytiga...
You might want to make sure your PSA hits 0.01 before you consider stopping Lupron. Our oncologist for example, continues therapy until PSA is <0.01, and stays that way for a number of months. There...
And even after the chemo, you still have the full arsenal of Xtandi, Zytiga and Xofigo to add to your treatment, if need be, which is good news in the long run. It is always hard to hear about a...
Father's PSA is now at 0.44, down from 0.75 last month. Still on ADT, now with Xtandi instead of Casodex. PSA still creeping down, hoping it'll reach 0.01 in the next few months. Arthur...
John, I would investigate the possibility of using estrogen patches (at 1mg dosage or similar). These have been used as third-line hormonal therapy for some time, and are also being studied in...
Hi Beth, This may be a moot point, since your husband failed Zytiga, and you've tried Xtandi, but it apparently takes Xtandi at least 4-5 weeks to reach a steady state in the blood stream, i.e. its...
So sorry to hear about your loss, please accept our sincere condolences. Arthur...
Mel, One thing to ask/find out as you decide on the various Supplemental Plan D options. In our case, my dad went with a supplemental Plan F coverage through AARP (United Health), and we discovered...
Cyclone, Like Allen and other have said on the thread, it might make a lot of sense to also add Xtandi or Zytiga together with your chemo. Since both are approved for the pre-chemo setting, combining...
Sounds like you've got a top team, and are applying full-court press on the PC front. Here's my best wishes for continued all around improvement on this cycle of treatments!! Arthur...
I'm not sure what I'm trying to say below, just working out ideas based on this interesting thread, so please bear with me :) Just to keep things in perspective, it is very true that cancer in humans...
It is that the F18 scan was done to check for bone mets. My Dad's bone mets showed on an F18, and at a PSA of around 14. He had gone from 0.7 (and no mets) to 15.5 in 8 months. So while we definitely...
I would second JNF's recommendation for aggressive treatment. The options depend on your preferences and your oncologist (regarding chemo + HT), but at the very least you should consider hitting your...
And, don't forget to walk across the Brooklyn Bridge (especially going from Brooklyn to Mahnhattan)! Arthur...
If not chemo, he can definitely switch his Casodex for Xtandi. Or, Zytiga. They are both available pre-chemo for mCRPC folks. Since you mention he's only got 3 bone mets, he might also be a candidate...
He was originally treated with IMRT (in 2001). So he won't be able to radiate the prostate, but a recent biopsy and DREs have been deemed normal. We think his mets are now originating from an initial...
Allen, I'm trying to understand why/how my Dad's Gleason 7 (3+4) diagnosed in 2000, after a ten year remission, and after one cycle of HT from 2011-2012, can now present with bone mets detected with...