11 Years for me with Gleason 9 and spinal bone met from the beginning. Startet iADT, but now leave intermittant and going for continues ADT. PSA still low: 0.014ng/ml. But it will not last forever,...
10 year anniversary this month for me since first diagnosis with Gleason 5 + 4 and bone metastases. After several radiation procedures, firstline ADT3 is still working, hm…...
Congrats Jerry, from anther Gleason-9 guy with bone mets right from the beginning, 9 years back. Like you I am still hormone sensitive and performing intermittent hormonal blockade (iADT) since then,...
In my opinion we have to be clear whether an early hormonal therapy might extend life, or not! Patrick Walsh, for example, thinks, that "So far, there has been no convincing scientific evidence to...
As far as I know, SERMS like Tamoxifene or Raloxifene increase Testosterone levels! I took a tiny dose of Toremifene in the beginning of the iADT OFF phase to speed up Testosterone regeneration....
Madagascar, I am diagnosed Feb. 2009 at the age of 51 with a PSA of 25ng/ml and GS 5+4, cT3a, Nx, but M1b setting, which is now called oligometastatic bone involvement. Have started ADT3 immediately...
Allen, yes, it was a one stop procedure, using the Siemens Biograph-nMR. This machine combines a 3T MRI and a PET scanner. It is not just a combination of two systems, because the PET and MRI scans...
Allen, the GA68-PSMA-PET/CT or PET/MRI is widely available in Germany and has a better sensitivity than a Cholin-PET. In the recurrent setting after primary therapy failure the detection rate is...
Quincy, not similar, but a bit in this direction. DX Jan 2009, aPSA:25, GS:5+4, cT3a, Nx M1b (spine + pelvic bones). I went for iADT+RT in 2009. Cholin Pet done 2012, during the1st iADT off phase...
Even in the UK there is some notable progress in survival of patients after a cancer diagnosis: “Cancer Research UK says that by the 2030s, it is realistic to expect that as many as three in every...
Shure you can! If you tell your doctor STOP he has to follow, but will give you some warnings. It is not safe to do so, if the patient has active bone metastases and is castration resistant! If he is...
I like to bring a case of oligomestastatic disease from Germany to your attention. This is a case, reported by Prof. Frederik Wenz from the University of Mannheim/Germany, who presented a case report...
Tony, I don’t think that the results from this study are ”game changing“ or “practice-changing” as said by the lead investigator Christopher Sweeney. The problems are the unclear pre study therapies....
Goodlife, To my knowledge, a PSA bounce can reach frightening levels. Statistically after about 18 months. This is only noticeable when not simultaneously ADT is performed, which in high-risk Pts....
Zufus, since Prostasol, we do know, that Estrogens have some effectiveness in PCA. To maintain bone-health I changed my ADT protocol, which I use during the 2nd ADT round, still not testosterone...
RCS, please have a look for Philips “Sonalleve MR-HIFU”. http://www.healthcare.philips.com/de_de/products/mri/systems/sonalleve/applications.wpd As far as I know it is approved in Germany for...
Special Lady, that’s the point: Diagnostics first, then comes the appropriate therapy! BTW: Thalidomide is more of an immunomodulator or stimulator than an VEGF Blocker, and that might be beneficial!...
Hi Dave, please have a look at the following presentation from Tom Pickles: http://www.urologyrounds.com/files/PDF/apr-9-08.pdf Page 23: So how much adjuvant ADT do men really need?...
Tony, according to the interesting Blair report Enzalutamide/XTANDI expires 2025, Abiraterone 2019:...
Janem123, with a PSA of less than 0.5ng/ml PET scan would be a waste of money!!! PSA must be at least 4ng/ml, a bit lower if PSADT is less than 3 month. Some basics:...
Hi SpecialLady, Yes, PET-MRI is a established procedure in PCA recurrence state! In Tübingen a comparison study is in progress, you get both PET-CT and PET-MRI. If interesting call Dr. Nina...
janem123, hi! Cholin-PET/CT is widely available in Germany. Some uses C11-Cholin, some F18-Cholin. C11-Cholin have a half-life on about 30 minutes, it must be processed in the clinic or nearby....
SpecialLady, i too disagree very strongly with TC! There are some/few cases of oligo metastatic disease which are curable, mostly by radiation or combination therapies. Cholin-PET/CT scan is widely...
An intresting retrospective analysis with 2550 patients by Zelefsky et.al., follow-up was 8 yr, extending >20 yr. http://www.europeanurology.com/article/S0302-2838(11)00897-9/fulltext Fig.1,2,3:...
Hubby's Advocate, there is an intresting study available for pT3B-N0-M0 patients. A multicenter study randomized 199 of these pts. to one of the following therapies: A: adjuvant RT B: androgen...
Special-Lady, perhaps you are thinking about my post in the "German PC forum", where we discuss Radiation failure and Tumor Markers, NE-Differentiation ect. Post-130:...
Wiesbaden - Germany...