I am hormone sensitive and on Xtandi alone, no other drug. T=~600 though of little use since Xtandi blocks T uptake everywhere. Started this protocol with Dr. Charles Myers in Nov '16 when during off...
In September I had two of my boyhood friends contact me, one from Seattle, the other Utah, and independently mention they would be going through Charlotte in October and would love to see me after...
(Joke coming) I think you had a cut rate prostatectomy. (rim shot) Honetsly, congratulations to you for survival and good results. I have a friend who had a psa rising to near 30 with a few biopsies...
I agree that the Radiation oncologist has completed his/her run. As to the period of Lupron, that can be decided by the patient in consultation with his specialist, whomever that may be. It is most...
All or almost all trials I have seen for advanced PCa treatments use OS or overall survival with some using CSS (or cause specific survival) as a subset. OS is unquestionably preferred because it...
BBfan Have not seen you since a while. I recall when you first posted somewhere else early on in your travel (I think). I, too was with Myers and when I transferred to Dr Drake at Columbia Presby he...
HIFU has no role to play in prostate cancer. It is approved to ablate tissue, such as an overlarge prostate. Any other use is experimental....
My Xtandi comes in such a bag with chemo labeling. I consider it to be as clean a bag as from a store and when I remove the vial I put the bag in our kitchen ziploc storage area. My wife removed the...
I have a friend who was diagnosed nearly 10 years ago with PCa with one met in the hip. He has been treated with drugs for the entire time. He had provenge a few years ago and is on Xtandi as part of...
I know a man whose results are similar to yours and his post op psa was 1.2. One node positive for him, cannot recall other pathology findings. He about shat his pants at the first psa but ADT+RT did...
https://link.springer.com/content/pdf/10.1007%2Fs00259-018-4167-0.pdf May have been poster earlier. This is from September 2018...
I have been in a local USToo group for years. It was helpful when I was diagnosed and shortly after. By the two year mark I had learned enough from members and the internet and my experience to be of...
Post XBRT radiation patients may have reduced immune responses as judged by the immune panel on blood tests. This is a known side effect and may take years to resolve. Enter your search terms online...
I rarely see ploidy (genetic mutation of tumor) mentioned anywhere, anecdotal results, pathology, research, but is ploidy as good or better predictor of these variables? Diploid HAS to be better than...
I have seen other studies that appear to verify that within the highest Gleason risk category of G8-10 that there are distinctions within the category. G 5 primary is certainly something. 2,3 or more...
Not directly like your situation but close enough. I had surgery 12 years ago at age 58. Continent at removal of catheter. After ten years I started having occasional leakage. Standing and fatigue...
Great work Jerry. As in my case the worry and anxiety early on were never confirmed and the online education from here and everywhere else (deleting the absurd and dangerous and adjusting for truly...
This poster is an example of how the science has advanced in a few years. 12 years ago I had post RP psa of 2.7, and 2 nodes positive excised. Consultation with three surgeons all said no option but...
AA Monotherapy can work: 2.5 years and counting I am a 12 year survivor of PCa. During an off period from Zoladex I had two mets, one in hip and one on spine. Restarting ADT and RT resolved the mets...
The molecular structure of Darolutamide is quite different from enzalutamide, apalutamide, bicalutamide and the androgen blockers drugs. This gives (me) hope that it has a lasting effect, perhaps...
12.5 years ago I had the same operation, psa 15.x, and the same post surgical pathology, 4+4(+5), and node positive, also age 58. Post surgical psa was 2.7. Yet here am I. I currently take two Xtandi...
I am Briova customer as well. My cost starts at 100$/month and remainder covered by my Part D insurer and after my insurer goes through donut hole then it drops to 0$/month. The donut hole says that...
Radiation statistics for prostate treatment tend to be affected by adverse selection bias. Patients are diagnosed by urologists who are surgeons. If the patient is not suitable for surgery due to...
The Messing trial (search for Immediate hormonal therapy compared with observation after radical prostatectomy and pelvic lymphadenectomy in men with node-positive prostate cancer) was the study that...
Regarding US approval of Euro drugs: For those of us with long memories the thalidomide tragedy still abides...
I had it a few years ago. I was completely uncomfortable for 24 hours. My body metabolism was upside down. I had heat flashes then chills and mind racing. Impossible to sleep. I tossed and turned for...
When Luprolide acetate was in testing the patients received their injection daily. Every day. It was to determine if the drug was as effective as surgical castration and later they began adjusting...
Mine is a bit different. After several on/off ADT periods I had a psa begin to rise while off and onc tried enzalutamide alone, one pill /day. It worked for a year then onc went to one/day 5 days per...
HIFU has not been approved in the US for treatment of prostate cancer. It has been approved for ablation of prostate tissue, for example hypertrophy (enlarged) prostate. Trials for cancer treatment...
AK: I have seen and have known men who changed to a dramatically lower fat, natural sourced, plant focused diet and their psa has slowed or even stopped its rise. For men with a small amount of tumor...
You posted some months ago that he had a 12 week post surgical psa of 4.8, a significant number and the reason for the androgen deprivation therapy. I believe your urologic surgeon is done now. He is...
I had IMRT for two bone lesions and further imaging found prostate bed tumor (several years post surgical). Pelvic nodes, bed and lesions received RT and I was on ADT. About ten months after T...
Peanut: I am on mono therapy Xtandi currently. The action of enzalutamide is that it stops the metabolism of T by the cells at the androgen receptor location on the surface of cells, including tumor...
In situations where there is no secondary more than 5% then the tertiary (if any) is reported thus (my situation): G4+4 (+5). Mine was nearly all G4, with less than 5% G5. The G5 was not enough to be...
Anuj, stop worrying about the details of psa. Your father had a biopsy and nothing of serious action was found. His age and chronic prostatitis means his psa will fluctuate and may never reach the...
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On Reddit there was (is?) a riddle of the day where someone posts a riddle and can answer questions yes or no to lead to inductive reasoning to find the answer. The riddle this day was "There is a...
It is unclear what the question is here. Time from metastases for men who have previously been treated with radiation or surgery and have progressed to a metastatic state? Men who are watching their...
I was touring a radiation treatment clinic with a group and after visiting the treatment area and the adjoining control room an older member of the group said to me that he had worked in a hospital...
My wife was diagnosed with breast cancer 18 months ago and then treated successfully, by all standards. Her mammogram was digital and flagged by the computer program which locates suspicious areas....
Last month I posted that a local oncologist said to my support group that the duration of hormone therapy was 18-24 months duration. Not specific to men with widespread metastases. All men on...
As an example, my wife was diagnosed with stage III ovarian cancer 30 months ago. Against my judgment she asked her surgeon/oncologist how the diagnosis would affect her life span. His reply was "I...
Leuprolide With and Without Flutamide in Advanced Prostate Cancer; E. David Crawford, 1986 Early androgen ablation for stage D1 (N1 to N3, M0) prostate cancer: prognostic variables and outcome; G....
Another person from the group asked the question and the GU MO is female. Just to keep the comment straight. She said that in response to my question if she were referring to men with presenting with...
Medical oncologist with GU specialty spoke to my support group last night. In response to the question "How long does hormone treatment last?" her response was 18-24 months. I questioned if she was...
https://www.ncbi.nlm.nih.gov/pubmed/28851578 IF studies in mice mean anything then darolutamide (ODM-201) may avoid resistance overlay with enzalutamide....
Yes, this is natural (in a sense of "natural"). The endocrine (hormone) system is self regulating. When disturbed, such as pharmacological reduction of testosterone, the body will adapt. When...
In retrospect one of the better (?) things about my disease progression is that I had two metastases during an off period from hormone treatment. The mets were radiated, along with bed and pelvic...
I am posting because my use is uncommon. I had 2 mets during an off period of ADT in 2012 followed by RT to mets and nodes and prostate bed (RP in 06). I continued on/off ADT until 2016 when my onc...
Same as Jerry, maybe longer....