Just wanted to give an update, I know it's been a few months. So I tried all the things that Pravda had in his patent, plus I had mesalamine pills, enemas, and i'm on Humira. All of that certainly...
Agreed, it just has to be stopped. There are too many things going on at once that contribute to worsening the original peroxide excess problem. That's why I think mesalamine and a little bit of...
So things have been interesting on my end. I'll start with what I'm taking right now: Multivitamin 2x day (no iron), two 30g whey protein shakes morning and night, 2x sodium butyrate morning and...
http://www.wjgnet.com/1007-9327/7/175.pdf This paper goes over the historical origins of where our concepts of what causes IBD have come from. It's a really interesting read. On page 6, it goes into...
I think it would be a conversation worth having with your doc. Rectal sparing and inflammation beginning in the transverse colon would seem to make it worth checking out. GI docs will generally take...
Ah, interesting. Has your doc ever considered Crohn's for you? Just curious. Regardless, the left side of the colon is generally harder to reach for oral meds/supplements. Stuff like ALA will affect...
my bad, I didn't check the date on that thread haha. I was like, "you should know this!" Also, FSLondon, if I recall, you are already pretty close to full remission? I think it would be harder to...
An update from me: Things have been slowly but surely getting better. I'm having more solidified stools and times where I'm having liquid stools are slowly becoming a thing of the past. Some days my...
Especially if we are low on transferase, which is primarily responsible for getting rid of xenobiotics and whatnot. Any b6 present in my supplements or diet doesn't seem to be that problematic for me...
Interesting, I didn't even think of differentiating between grey hair and white hair. I sometimes have white hairs pop up in interesting places on my body and thought I can't fully tell, it seems...
Glutathione peroxidase was the one I was hyper focused on, since Pravda emphasized its peroxide neutralizing action in his original paper. Regardless of glutathione levels, excess peroxide/ROS/RNS is...
Back for a little update. I did a search on reduced glutathione and UC as well as other antioxidant levels. Many more studies done in recent years will find reduced levels of antioxidants, which...
Thanks for advice guys. I have some canasa samples at home, I think I'm gonna start using those and start up metamucil. In case that doesn't work, does anyone know if miralax is harmful to UC? What...
I've been reading how an inflamed rectum will cause constipation and such. I guess I'm curious as to how it causes constipation when my rectum has basically always been inflamed? Is it that when the...
Hi everyone, Things have been getting better for me UC wise, and the frequency and urgency of my bowel movements has significantly diminished, to the point where I'm edging on constipation. I've been...
Personally, i'm doing a combination of finding out what will increase glutathione/reduce H2O2 inside the cell and what pravda is doing with his own patients. Beta oxidation is impaired but that...
Yes, lots of stuff going on. Just trying to make sense of the glutathione levels. Pravda has not responded to my second email, will try again in a week or two if no response. There is upregulation at...
Hmmm, interesting. Perhaps in the early stages of disease the body might upregulate glutathione and then in becomes depleted as active disease carries on, ROS load becomes too great, malnutrition...
OM, Had an idea about that 1995 study finding normal glutathione levels in UC patients and normal controls. What if glutathione is upregulated in response to oxidative stress? You think upregulated...
I'll be sure to run it by him. He hasn't responded yet, but it seems he checks his emails every week or so....
My transit time has seemed to slow down a lot, as I can not feel an urge to go for about 5-6 hours now and when I do it's really easy to hold it in, but I think the slower transit time is not good to...
That is so weird, I totally imagined Gary being in his 30s too. Maybe because he is so cool :)...
Regarding teaching redox chem/biochem in school, As a biochem student in the last few years, I personally was annoyed any time we went into redox biochemistry in class. It was a subject with lots of...
Pravda responded to my email. I basically asked him about the status of RIT in the scientific community and why nobody seemed to be discussing it as well as what his approach to treating patients is...
The first study was a little too jargon heavy for me to fully understand, but from what it seems like, LDN reduces INTRACELLULAR (within the cell) peroxide? To play Devil's advocate, people could be...
In any case, it seems that with the India UC patients study, the redox status of Ashkenazi populations being lower on average, and a few other studies, I think there is still a good amount of...
OM, what do you make of the fact that the other antioxidant levels are normal from this study?...
Also looked at the trial again, he used cromolyn sodium in the enema, which at first glance seemed to be an antihistamine, but also has strong antioxidant properties as well....
I'd imagine trying to quell the inflammation should be done at the same time. I mean if we are having tissue destruction and more h2o2 production from the immune system, that would prevent the...
Yeah, apparently cysteine is fragile but when cysteines combine into cystine, it is more stable. That's the selling point for immunocal, but again, not sure if regular whey will do the same thing....
I was just thinking about how DIY FMT...and most FMT in general is done with lots of exposure to air which does reduce the number of anaerobes really quickly. Perhaps its the anaerobes that are more...
Will take a look at it, but I would be reluctant to trust that taurine is the key to it all. There's a lot going on here that we can look at theoretically, but would vary biochemically in reality...
Apologies for the lack of posting OM, still really interested in this, but have been pretty busy (fortunately, it's been a long time since I had real things to do!) One thought I had in light of this...
Finished the initial paper, read it way more in depth and I like what I'm reading. At the very least, it's a VERY compelling argument for the cause of UC, and I'm still impressed by how many...
Read half of it more in depth today. Really find it intriguing how much ground was covered. Why smoking cessation is associated with UC, why sudden decrease in stress would be associated with it (I...
Just skimmed the paper by Jay Pravda on the overview of RIT. This seems really comprehensive and fits everything we've read about UC into a cohesive theory. I came across the article on the small...
Will take some time to read into the info here. edit: Is there any info out there on how gut bacteria or antibiotics fit into this theoretical framework?...
For some reason, i'm okay w/ fecal transplants more than I'm okay with the idea of putting someone elses plaque in my mouth. Blegh. Still very cool to see the strong interest in how bacteria affects...
It's true, any wacky theories I may have should not be considered true, but it is interesting to try and put the pieces together. From what I've read, the things being discussed aren't particularly...
True, who knows, we could be normal people having a normal immune response to bacteria that aren't where they should be. Vitamin A+D contributes to antimicrobial peptides in the gut, wonder if that...
A blender does introduce oxygen killing off the anaerobix bacteria, but you'll still have some if you prepare everything pretty quickly. Make sure to submerge the stool in saline as soon as you can....
OM, have you looked into how bacteria might be flushed from the mucus layer if they are to get inside? How does the body work to get rid of that bacteria? Also, I was pondering about this today......
Agreed, no more throwing small molecules at people and seeing what sticks. Makes drug development way less risky too, which is good for people. Mongersen has entered phase III trials which are set...
Regarding the serial FMT study: Really glad they are looking at multiple FMTs and how it affects gene expression. I have yet to read it more fully as that doc won't open on my computer, it only opens...
This is a good point. I realized in my post that the same could probably be said with or without biofilm. Perhaps the biofilm explanation would account for why mucus doesn't readily rebuild itself...
Lol, Old Mike, Tunnelvisionary, Canada Mark, and Dreadsteel are pubmed heads for sure. I wonder if they'd do my taxes...[/quote] Being a biochem major about to graduate, I should be grateful for...
Very interesting...I did not know this and this seems to be a pretty big fact. My nurse practitioner at my GI's office (who I consider to be way more knowledgeable and up to date with respect to IBD...
This talk about biofilms makes me wonder if its possible for anyone to get UC. I was reading this paper on exactly where we are with regards to IBD pathogenesis...
I know they've shown in rat models of colitis that bacterial diversity is associated with a thicker/stronger mucus layer. Do we have anymore papers on that? I ask because in May of 2013, I caught a...
Also, with every FMT for UC study coming out, it's important to note that the vast majority of them conduct one or two (if even that) transplants. Anecdotes suggest that that is not nearly enough to...